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| Content Provider | Springer Nature Link |
|---|---|
| Author | Laberge, Remi Martin Awad, Pierre Campisi, Judith Desprez, Pierre Yves |
| Copyright Year | 2011 |
| Abstract | Depending on the cell type and tissue environment, epithelial and mesenchymal cell phenotypes are not static and can be highly dynamic. Epithelial-mesenchymal transitions (EMTs) and reverse EMTs provide flexibility during embryogenesis. While EMTs are a critical normal process during development and wound healing, properties of the EMT have been implicated in human pathology, particularly cancer metastasis. A normal undamaged epithelium does not typically exhibit features of an EMT. However, particularly under the influence of the surrounding microenvironment, cancer cells may reactivate developmental phenotypes out of context in the adult. This reactivation, such as the EMT, can facilitate tumor cell invasion and metastasis, and therefore is a major mechanism of tumor progression. Conversely, cellular senescence, which is associated with aging, is a process by which cells enter a state of permanent cell cycle arrest, thereby constituting a potent tumor suppressive mechanism. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretory phenotype (SASP) that turns senescent fibroblasts into pro-inflammatory cells having the ability to promote tumor progression, in part by inducing an EMT in nearby epithelial cells. Here, we summarize the potential impacts of SASP factors, particularly interleukins, on tissue microenvironments and their ability to stimulate tumor progression through induction of an EMT. |
| Starting Page | 39 |
| Ending Page | 44 |
| Page Count | 6 |
| File Format | |
| ISSN | 18752292 |
| Journal | Cancer Microenvironment |
| Volume Number | 5 |
| Issue Number | 1 |
| e-ISSN | 18752284 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2011-06-25 |
| Publisher Institution | International Cancer Microenvironment Society |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | Aging Senescence Cytokines Interleukins Proliferation Invasion Migration Biomedicine general Biochemistry Immunology Cell Biology Oncology Cancer Research |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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