CDC20 promotes the progression of hepatocellular carcinoma by regulating epithelial‑mesenchymal transition.

Content Provider	Europe PMC
Author	Yang, Gang Wang, Guan Xiong, Yongfu Sun, Ji Li, Weinan Tang, Tao Li, Jingdong
Copyright Year	2021
Abstract	Hepatocellular carcinoma (HCC) is a type of primary liver cancer, which is associated with high mortality. HCC is one of the most common malignant tumors worldwide. Cell division cycle 20 (CDC20) has been reported to be associated with the development of various malignant tumors and epithelial-mesenchymal transition (EMT) has been reported to be involved in the malignant metastasis of HCC. Therefore, the present study hypothesized that CDC20 may participate in the malignant biological behavior of HCC via EMT. The present study analyzed the expression levels of CDC20 in HCC and the association between CDC20 and poor prognosis. Furthermore, the effects of CDC20 on the proliferation, invasion and migration of HCC cells were examined using proliferation, migration and invasion assays. Finally, alterations in EMT were analyzed. The results revealed that CDC20 was highly expressed in HCC and HCC cell lines (P<0.05), and its high expression level was significantly associated with poor prognosis in patients with HCC (P<0.05). CDC20 silencing inhibited the proliferation, migration and invasion of HCC cells. Furthermore, CDC20 silencing increased the expression levels of E-cadherin, and decreased the expression levels of N-cadherin, vimentin and Ki-67. In conclusion, the present study reported that CDC20 may be a novel therapeutic target in HCC and CDC20 could promote the progression of HCC by regulating EMT.
ISSN	17912997
Journal	Molecular Medicine Reports
Volume Number	24
PubMed Central reference number	PMC8127032
Issue Number	1
PubMed reference number	33907851
e-ISSN	17913004
DOI	10.3892/mmr.2021.12122
Language	English
Publisher	D.A. Spandidos
Publisher Date	2021-04-28
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Yang et al.
Subject Keyword	cell division cycle 20 epithelial-mesenchymal transition hepatocellular carcinoma proliferation migration invasion
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Biochemistry Cancer Research Molecular Medicine Oncology