NDLI: Enhanced photodynamic therapy of mixed phase TiO$_{2}$(B)/anatase nanofibers for killing of HeLa cells

Content Provider	Springer Nature Link
Author	Zhang, Shuchao Yang, Dongjiang Jing, Dengwei Liu, Hongwei Liu, Long Jia, Yi Gao, Meihua Guo, Liejin Huo, Ziyang
Copyright Year	2014
Abstract	Photodynamic therapy (PDT), which is a procedure that uses photosensitizing drug to apply therapy selectively to target sites, has been proven to be a safe treatment for cancers and conditions that may develop into cancers. Nano-sized TiO$_{2}$ has been regarded as potential photosensitizer for UV light driven PDT. In this study, four types of TiO$_{2}$ nanofibers were prepared from proton tri-titanate (H$_{2}$T$_{3}$O$_{7}$) nanofiber. The as-obtained nanofibers were demonstrated as efficient photosensitizers for PDT killing of HeLa cells. MTT assay and flow cytometry (FCM) were carried out to evaluate the biocompatibility, percentage of apoptotic cells, and cell viability. The non-cytotoxicity of the as-prepared TiO$_{2}$ nanofibers in the absence of UV irradiation has also been demonstrated. Under UV light irradiation, the TiO$_{2}$ nanofibers, particularly the mixed phase nanofibers, displayed much higher cell-killing efficiency than Pirarubicin (THP), which is a common drug to induce the apoptosis of HeLa cells. We ascribe the high cellkilling efficiency of the mixed phase nanofibers to the bandgap edge match and stable interface between TiO$_{2}$(B) and anatase phases in a single nanofiber, which can inhibit the recombination of the photogenerated electrons and holes. This promotes the charge separation and transfer processes and can produce more reactive oxygen species (ROS) that are responsible for the killing of HeLa cells.
Starting Page	1659
Ending Page	1669
Page Count	11
File Format	PDF
ISSN	19980124
Journal	Nano Research
Volume Number	7
Issue Number	11
e-ISSN	19980000
Language	English
Publisher	Tsinghua University Press
Publisher Date	2014-08-29
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	photodynamic therapy titanium oxides (TiO$_{2}$) nanomaterials apoptosis mixed phase Nanotechnology Materials Science Atomic/Molecular Structure and Spectra Condensed Matter Physics Biotechnology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Electrical and Electronic Engineering

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