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| Content Provider | Springer Nature Link |
|---|---|
| Author | Dobos, Judit Kenessey, István Tímár, József Ladányi, Andrea |
| Copyright Year | 2011 |
| Abstract | Glucocorticoids, such as dexamethasone are widely used in cancer therapy and have cell type-specific pro- or antiapoptotic effects. We examined whether melanoma cells are sensitive to dexamethasone treatment. We have demonstrated for the first time that in human melanoma cell lines as well as in benign and malignant melanocytic tumors glucocorticoid receptor (GCR) is present both at mRNA and protein level. Dexamethasone applied at high doses inhibited the in vitro growth of WM983A human melanoma cells. The inhibitory effect was due to apoptosis induction. In the case of this relatively sensitive cell line dexamethasone enhanced the effect of the chemotherapeutic drug DTIC. |
| Starting Page | 729 |
| Ending Page | 734 |
| Page Count | 6 |
| File Format | |
| ISSN | 12194956 |
| Journal | Pathology & Oncology Research |
| Volume Number | 17 |
| Issue Number | 3 |
| e-ISSN | 15322807 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2011-04-01 |
| Publisher Place | Dordrecht |
| Access Restriction | Subscribed |
| Subject Keyword | Apoptosis Chemotherapy Dexamethasone Glucocorticoid receptor Melanoma Pathology Immunology Oncology Cancer Research Biomedicine general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pathology and Forensic Medicine Oncology |
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