NDLI: Expression of p53, Ki-67 and c-Myc Proteins is Predictive of the Surgical Molecular Margin in Colorectal Carcinoma

Content Provider	Springer Nature Link
Author	Li, Nan Wang, Jingmei Shen, Shanshan Bu, Xiaodong Tian, Xiaoqiang Huang, Peilin
Copyright Year	2011
Abstract	Surgical resection is the mainstay of treatment for colorectal carcinoma, however, the overall survival is modest due to frequent local recurrence from residual cancer cells after “curative” resection. Therefore, the status of surgical margin (tumor free or positive) has a significant influence on patient’s survival. The difference in molecular profile between mucosa neighboring tumor lesions and remote area (surgical margin) may aid in evaluating resection status. 44 colorectal tumor tissues with corresponding adjacent non-neoplastic mucosa (within 3 cm from tumor tissues), and 110 tumor tissues with corresponding surgical margin mucosa (5 cm from tumor tissues) were randomly collected, fixed in 10% formalin and followed by embedding in paraffin. And the expression of p53, Ki-67 and c-Myc were investigated by tissue microarray (TMA) and immunohistochmistry. The expression of p53, Ki-67 and c-Myc were decreased in both adjacent non-neoplastic mucosa and mucosa of surgical margin, comparing to their expression in corresponding cancer cells. Furthermore, the expression of these proteins in mucosa of remote area (surgical margin) was significantly lower than those adjacent to tumor lesions. The expression of p53, Ki-67 and c-Myc in mucosa can be used as molecular marker for assessing surgical margin status in colorectal carcinoma.
Starting Page	479
Ending Page	487
Page Count	9
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	17
Issue Number	3
e-ISSN	15322807
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-02-05
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Colorectal carcinoma Surgical molecular margin p53 Ki-67 c-Myc Pathology Immunology Oncology Cancer Research Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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