NDLI: Estrogen Receptor Negative and Progesterone Receptor Positive Breast Carcinomas

Content Provider	Springer Nature Link
Author	Cserni, Gábor Francz, Monika Kálmán, Endre Kelemen, Gyöngyi Komjáthy, Detre Csaba Kovács, Ilona Kulka, Janina Sarkadi, László Udvarhelyi, Nóra Vass, László Vörös, András
Copyright Year	2011
Abstract	Estrogen receptor (ER) testing has become an important part of breast cancer reporting as the ER status is a predictor of hormonal treatment efficacy. Progesteron receptors (PR) are often tested in parallel, and the best response to hormonal manipulations can be expected in tumors positive for both receptors. The existence of breast cancers with an ER negative and PR positive phenotype is controversial. A series of cases with this phenotype were reevaluated to clarify the existence and the frequency of this entity. A total of 205/6587 (3.1%; range of the rate per department: 0.3–7.1%.) cases reported to have the ER-negative and PR-positive status by immunohistochemistry were collected from 9 Hungarian departments. After careful reevaluation of the tumor slides and control tissues with a 1% cut-off for positivity and restaining of the questionable cases, all but 1 of the reevaluable 182 cases changed their original phenotype. Most cases converted to dual positives (n = 124) or dual negatives (n = 31) or unassessable / questionable. ER-negative and PR-positive breast cancers are very rare if existing. Such a phenotype should prompt reassessment.
Starting Page	663
Ending Page	668
Page Count	6
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	17
Issue Number	3
e-ISSN	15322807
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-01-26
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Breast cancer Estrogen receptor Progesterone receptor Immunohistochemistry Estrogen receptor-negative progesterone receptor-positive breast cancer Pathology Immunology Oncology Cancer Research Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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