NDLI: Association of P53 (−16ins-Pro) Haplotype with the Decreased Risk of Differentiated Thyroid Carcinoma in Iranian-Azeri Patients

Content Provider	Springer Nature Link
Author	Dehghan, Roghayeh Hosseinpour Feizi, Mohammad Ali Pouladi, Nasser Babaei, Esmaeil Montazeri, Vahid Fakhrjoo, Ashraf Sedaei, Ayda Azarfam, Parvin Nemati, Masoumeh
Copyright Year	2014
Abstract	Association of P53 polymorphisms with the increased risk of various cancers has been investigated in numerous studies. However, the results were conflicting and no polymorphism has been determined as a definite risk factor. It is likely that the study of P53 combined genotypes and haplotypes may be more useful than individual polymorphisms. Thus, in this study, we analyzed the associations of intron 3 Ins16bp and exon 4 Arg72Pro polymorphisms, as well as their combined genotypes and haplotypes with the risk of differentiated thyroid carcinoma in Iranian-Azeri patients. This case–control study was performed on 84 Iranian Azeri patients with differentiated thyroid carcinoma and 150 healthy subjects. Intron 3 genotype was determined using PCR products analysis on polyacrylamide gels and AS-PCR was used for genotyping Arg72Pro polymorphism. The javastat online statistics package software and SHEsis program were applied for data analysis. There was no significant difference in genotype frequencies of both two polymorphisms between cases and controls. However, the (−16ins/−16ins) (Arg/Pro) genotype combination had a noticeable but not significant association with decreased risk of thyroid cancer development (OR = 0.497 95%CI: 0.209–1.168 P =0.080) and also the frequency of (−16ins-Pro) haplotype was significantly higher in controls rather than patients (OR = 0.543 95%CI: 0.326–0.903 P =0.018). In our study, there was association between (−16ins-Pro) haplotype with decreased risk of differentiated thyroid carcinoma development in Iranian-Azeri patients.
Starting Page	449
Ending Page	454
Page Count	6
File Format	PDF
ISSN	12194956
Journal	Pathology & Oncology Research
Volume Number	21
Issue Number	2
e-ISSN	15322807
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-11-20
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Thyroid Neoplasms P53 tumor suppressor protein Polymorphism Haplotype Molecular marker Cancer Research Oncology Pathology Immunology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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