NDLI: Association between SNPs in P53 binding regions and risk of esophageal squamous cell carcinoma.

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Association between SNPs in P53 binding regions and risk of esophageal squamous cell carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Kai Liu, Botao Li, Juan Xiong, Gang Guan, Xingying Yang, Kang Bai, Yun
Description	Author Affiliation: Wang K ( Department of Medical Genetics, Third Military Medical University, Chongqing - China.)
Abstract	BACKGROUND: The tumor protein 53 (TP53 or p53) plays an important role in tumor suppression by binding to the regulatory region of its target genes. Single nucleotide polymorphisms (SNP) located in the p53 binding regions are likely to affect the expression of p53 target genes and may contribute to susceptibility to common diseases. The role of the genetic variations in esophageal squamous cell carcinoma (ESCC) has been well explored. However, the role of p53 binding region variations in esophageal cancer is poorly understood. METHODS: We investigated the association of 6 p53 binding region polymorphisms with susceptibility of 400 ESCC cases and 400 cancer-free controls in a Southwest Chinese population using the SNapShot assay. Differences in frequencies of the SPNs genotypes between cases and controls were evaluated using the chi-square test. RESULTS: We found that the C allele of rs1009316 in Bax and rs762624 in CDKN1A can decrease the risk of ESCC. In the multiple genetic model, we found that the rs2395655 in CDKN1A is related with the risk of ESCC, and that the G allele increases the susceptibility to ESCC (OR: 1.364; 95% CI: 1.104-1.685). We carried out a stratification analysis between alleles and risk of ESCC according to clinical stage. There was no relationship between these SNPs and clinical stage. CONCLUSION: SNPs in the p53 binding region may modulate the risk of ESCC in the Southwest Chinese population.
File Format	HTM / HTML
ISSN	03936155
Issue Number	2
Volume Number	29
e-ISSN	17246008
Journal	The International Journal of Biological Markers
Language	English
Publisher	Sage Publications
Publisher Date	2014-06-25
Publisher Place	Italy
Access Restriction	Subscribed
Subject Keyword	Discipline Biochemistry Discipline Oncology Carcinoma, Squamous Cell Genetics Esophageal Neoplasms Genes, P53 Binding Sites Female Genetic Predisposition To Disease Genotype Humans Male Middle Aged Polymorphism, Single Nucleotide Tumor Suppressor Protein P53 Metabolism Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Clinical Biochemistry Cancer Research Pathology and Forensic Medicine Oncology

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