NDLI: PPAR-Mediated diverse responses in various tissues of mouse

Content Provider	Springer Nature Link
Author	Motojima, Kiyoto
Copyright Year	2000
Abstract	Peroxisome proliferator-activated receptors (PPARs) play the essential role in transcriptional modulations of the genes involved in lipid metabolism. In vitro studies have shown that all the mechanisms of the modulations are similarly mediated by PPAR and the response elements through heterodimerization with retinoid X receptors (RXRs). However, PPARs mediate the diverse effects induced in various tissues of mouse by their activators. First, PPARα also plays an obligatory role in the activator-induced transcriptional modulations of various genes, some of which are not related to lipid metabolism. Second, responsiveness of various genes to several activators varies considerably. Third, some of the activator-induced transcriptional activation of several genes is strictly tissue-specific. Fourth, the time courses of the activator-induced transcriptional modulations are diverse. Following brief review of these diverse responses, emphasis is laid on the need for studies of these diversely regulated genes to understand the species-general and coordinated interplay between PPARs and other factors to maintain lipid homeostasis at the body level.
Starting Page	205
Ending Page	211
Page Count	7
File Format	PDF
ISSN	10859195
Journal	Cell Biochemistry and Biophysics
Volume Number	32
Issue Number	1-3
e-ISSN	15590283
Language	English
Publisher	Humana Press
Publisher Date	2000-01-01
Publisher Place	Totowa
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biochemistry Pharmacology/Toxicology Biotechnology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Biochemistry Biophysics

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