NDLI: Dietary Selenium (Se) and Vitamin E (V$_{E}$) Supplementation Modulated Methylmercury-Mediated Changes in Markers of Cardiovascular Diseases in Rats

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Dietary Selenium (Se) and Vitamin E (V$_{E}$) Supplementation Modulated Methylmercury-Mediated Changes in Markers of Cardiovascular Diseases in Rats

Content Provider	Springer Nature Link
Author	Jin, Xiaolei Hidiroglou, Nick Lok, Eric Taylor, Marnie Kapal, Kamla Ross, Nikia Sarafin, Kurtis Lau, Andrea Souza, Andrea Chan, Hing Man Mehta, Rekha
Copyright Year	2011
Abstract	Epidemiological studies demonstrated that human exposure to methylmercury (MeHg) may contribute to the development and progression of metabolic and cardiovascular disorders. However, the mechanisms involved and the role of selenium (Se) and vitamin E (V$_{E}$) supplementation in modulating MeHg cardiovascular toxicities remain unclear. This study examined the effects of Se and V$_{E}$ supplementation on MeHg-mediated systemic oxidative stress, antioxidant defense, inflammation, and endothelial dysfunction in an animal model. Male Sprague–Dawley rats were fed a starch-based casein diet or the same diet supplemented with 1 or 3 mg Se/kg diet and with or without 250 or 750 mg V$_{E}$/kg diet. After 28 days of dietary treatment, rats were gavaged with 0 or 3 mg MeHg/kg BW for 14 consecutive days. Results suggested that exposure to MeHg may increase the risk of cardiovascular disease by decreasing circulating paraoxonase-1 activities, increasing serum oxidized low density lipoprotein levels, and associated systemic inflammation and endothelial dysfunction as reflected by increased leukocyte counts and serum levels of intercellular adhesion molecule-1 and monocyte chemotactic protein-1. Se and V$_{E}$ supplementation may either alleviate or augment the effects of MeHg, depending on their doses and combinations.
Starting Page	10
Ending Page	24
Page Count	15
File Format	PDF
ISSN	15307905
Journal	Cardiovascular Toxicology
Volume Number	12
Issue Number	1
e-ISSN	15590259
Language	English
Publisher	Humana Press Inc
Publisher Date	2011-08-06
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Methylmercury Oxidative stress Cardiovascular disease 8-Hydroxydeoxyguanosine Isoprostane Oxidized LDL Selenium Vitamin E Paraoxonase Total antioxidant capacity C-reactive protein Protein carbonyl Intercellular adhesion molecule-1 Monocyte chemotactic protein-1 Cardiology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Toxicology Cardiology and Cardiovascular Medicine

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Dietary Selenium (Se) and Vitamin E (V$_{E}$) Supplementation Modulated Methylmercury-Mediated Changes in Markers of Cardiovascular Diseases in Rats

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Dietary Selenium (Se) and Vitamin E (V$_{E}$) Supplementation Modulated Methylmercury-Mediated Changes in Markers of Cardiovascular Diseases in Rats