NDLI: Bilirubin Attenuates Bufadienolide-Induced Ventricular Arrhythmias and Cardiac Dysfunction in Guinea-Pigs by Reducing Elevated Intracellular Na$^{+}$ Levels

Please wait, while we are loading the content...

Mechanistic Clues in the Protective Effect of Ellagic Acid Against Apoptosis and Decreased Mitochondrial Respiratory Enzyme Activities in Myocardial Infarcted Rats

Cardiac Tissue Injury Resistance During Myocardial Infarction at Adulthood by Developmental Exposure to Cadmium

Standardized Flavonoid-Rich Eugenia jambolana Seed Extract Retards In Vitro and In Vivo LDL Oxidation and Expression of VCAM-1 and P-Selectin in Atherogenic Rats

Bilirubin Attenuates Bufadienolide-Induced Ventricular Arrhythmias and Cardiac Dysfunction in Guinea-Pigs by Reducing Elevated Intracellular Na$^{+}$ Levels

Huffing-Induced Cardiomyopathy: A Case Report

Cardiovascular Toxicology : Volume 11

Cardiovascular Toxicology : Volume 10

Cardiovascular Toxicology : Volume 9

Cardiovascular Toxicology : Volume 8

Cardiovascular Toxicology : Volume 7

Cardiovascular Toxicology : Volume 6

Cardiovascular Toxicology : Volume 5

Cardiovascular Toxicology : Volume 4

Cardiovascular Toxicology : Volume 3

Cardiovascular Toxicology : Volume 2

Cardiovascular Toxicology : Volume 1

Bilirubin Attenuates Bufadienolide-Induced Ventricular Arrhythmias and Cardiac Dysfunction in Guinea-Pigs by Reducing Elevated Intracellular Na$^{+}$ Levels

Content Provider	Springer Nature Link
Author	Ma, Hongyue Zhang, Junfeng Jiang, Jiejun Zhou, Jing Xu, Huiqin Zhan, Zhen Wu, Qinan Duan, Jinao
Copyright Year	2011
Abstract	Bufadienolides, known ligands of the sodium pump, have been shown to inhibit the proliferation of several cancer cell types. However, their development to date as anticancer agents has been impaired by a narrow therapeutic margin resulting from their potential to induce cardiotoxicity. In the present study, we examined the effects of bilirubin, an endogenous antioxidant, on the cardiotoxicity of bufadienolides (derived from toad venom) in guinea-pigs. The results showed that bufadienolides (8 mg/kg) caused ventricular arrhythmias, conduction block, cardiac dysfunction and death in guinea-pigs. Pretreatment with bilirubin (75 and 150 mg/kg) significantly prevented bufadienolide-induced premature ventricular complexes, ventricular tachycardia, ventricular fibrillation and death. Bilirubin also markedly improved the inhibition of cardiac contraction in bufadienolide-treated guinea-pigs as evidenced by increases in left ventricular systolic pressure and decreases in left ventricular diastolic pressure in vivo. Furthermore, bilirubin significantly reduced the intracellular sodium content ([Na$^{+}$]$_{ i }$) in ex vivo bufadienolide-stimulated guinea-pig ventricular myocytes loaded with the sodium indicator Sodium Green. An antitumor study showed that bilirubin did not compromise the ability of bufadienolides to inhibit gastric cancer cell MGC-803 proliferation. These results suggested that bilirubin can attenuate bufadienolide-induced arrhythmias and cardiac dysfunction in guinea-pigs by reducing elevated [Na$^{+}$]$_{ i }$ and may improve bufadienolide therapeutic index in cancer treatment.
Starting Page	83
Ending Page	89
Page Count	7
File Format	PDF
ISSN	15307905
Journal	Cardiovascular Toxicology
Volume Number	12
Issue Number	1
e-ISSN	15590259
Language	English
Publisher	Humana Press Inc
Publisher Date	2011-11-30
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Bilirubin Bufadienolides Arrhythmias Cardiac dysfunction Anticancer agents Cardiology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Toxicology Cardiology and Cardiovascular Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cardiac overexpression of metallothionein attenuates chronic alcohol intake-induced cardiomyocyte contractile dysfunction

Antiplatelet Agents Sarpogrelate and Cilostazol Affect Experimentally-induced Ventricular Arrhythmias and Mortality

Effect of $Na^{+}/Ca^{2+}$ exchange inhibitor, KB-R7943 on ouabain-induced arrhythmias in guinea-pigs

Cardiac Arrhythmias Induced by Chloral Hydrate in Rhesus Monkeys

Intracellular Levels of Na$^{+}$ and TTX-sensitive Na$^{+}$ Channel Current in Diabetic Rat Ventricular Cardiomyocytes

Valsartan, an Angiotensin II Receptor Blocker, Attenuates Cardiac Dysfunction and Oxidative Stress in Isoproterenol-Induced Cardiotoxicity

Protective Role of Antioxidants in Diabetes-Induced Cardiac Dysfunction

Cardiac-Specific Knockout of ET$_{A}$ Receptor Mitigates Paraquat-Induced Cardiac Contractile Dysfunction

Biomarkers in Atrial Fibrillation, Ventricular Arrhythmias, and Sudden Cardiac Death

Bilirubin Attenuates Bufadienolide-Induced Ventricular Arrhythmias and Cardiac Dysfunction in Guinea-Pigs by Reducing Elevated Intracellular Na$^{+}$ Levels

Similar Documents

Cardiac overexpression of metallothionein attenuates chronic alcohol intake-induced cardiomyocyte contractile dysfunction

Antiplatelet Agents Sarpogrelate and Cilostazol Affect Experimentally-induced Ventricular Arrhythmias and Mortality

Effect of $Na^{+}/Ca^{2+}$ exchange inhibitor, KB-R7943 on ouabain-induced arrhythmias in guinea-pigs

Cardiac Arrhythmias Induced by Chloral Hydrate in Rhesus Monkeys

Intracellular Levels of Na$^{+}$ and TTX-sensitive Na$^{+}$ Channel Current in Diabetic Rat Ventricular Cardiomyocytes

Valsartan, an Angiotensin II Receptor Blocker, Attenuates Cardiac Dysfunction and Oxidative Stress in Isoproterenol-Induced Cardiotoxicity

Protective Role of Antioxidants in Diabetes-Induced Cardiac Dysfunction

Cardiac-Specific Knockout of ET$_{A}$ Receptor Mitigates Paraquat-Induced Cardiac Contractile Dysfunction

Biomarkers in Atrial Fibrillation, Ventricular Arrhythmias, and Sudden Cardiac Death

Bilirubin Attenuates Bufadienolide-Induced Ventricular Arrhythmias and Cardiac Dysfunction in Guinea-Pigs by Reducing Elevated Intracellular Na$^{+}$ Levels