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| Content Provider | Springer Nature Link |
|---|---|
| Author | Karyala, Saikumar Guo, Junhai Sartor, Maureen Medvedovic, Mario Puga, Alvaro Ryan, Patrick Tomlinson, Craig R. |
| Copyright Year | 2004 |
| Abstract | Benzo[a]pyrene (B[a]P) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are potent ligands for the aryl hydrocarbon receptor (AHR). High-density oligonucleotide microarrays were used to generate global gene expression profiles of wild-type and Ahr $^{−/−}$ vascular smooth muscle cells (SMCs) from mouse aorta. To determine whether there are signaling pathways other than the AHR involved in B[a]P metabolism, wild-type and AHR knockout (Ahr $^{−/−}$ SMCs were exposed to B[a]P. Two signaling pathways, represented by TGF-β2 and IGF-1, were identified as potential candidates of an AHR alternate pathway for cells to respond to B[a]P. The wild-type SMCs responded similarly to B[a]P and TCDD in the regulation of a small set of common genes known to respond to the activated AHR (e.g., glutamine S-transferase). However, wild-type SMCs responded in a way that involves many additional genes, suggesting that a very divergent cellular response may be involved when SMCs are exposed to the two classic inducers of the AHR. In contrast, many more genes in the Ahr $^{−/−}$ cells responded similarly to B[a]P and TCDD, inducluding Cyp1b1, than responded differently, which indicates that eliminating the AHR is effective for investigating potential alternate cellular mechanisms that respond to B[a]P and TCDD. |
| Starting Page | 47 |
| Ending Page | 73 |
| Page Count | 27 |
| File Format | |
| ISSN | 15307905 |
| Journal | Cardiovascular Toxicology |
| Volume Number | 4 |
| Issue Number | 1 |
| e-ISSN | 15590259 |
| Language | English |
| Publisher | Humana Press |
| Publisher Date | 2004-01-01 |
| Publisher Place | Totowa |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Aryl hydrocarbon receptor transforming growth factor-β benzo [a]pyrene dioxin, aorta microarrays gene expression profiles mous smooth muscle cells Pharmacology/Toxicology Cardiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Molecular Biology Toxicology Cardiology and Cardiovascular Medicine |
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