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Inhibition of cardiac myocyte contraction by 4-hydroxy-trans-2-nonenal

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Inhibition of cardiac myocyte contraction by 4-hydroxy-trans-2-nonenal

Content Provider	Springer Nature Link
Author	Aberle, Nicholas S. Picklo, Matthew J. Amarnath, Venkataraman Ren, Jun
Copyright Year	2004
Abstract	Lipid peroxidation, initiated by hydroxyl radicals, results in production of 4-Hydroxy-trans-2-nonenal (HNE) and leads to cardiac injury. However, impact of HNE on ventricular function has not been clearly defined. This study was to examine the direct effect of HNE on cardiac contractile function at cardiac myocyte level. Adult, male rat ventricular myocytes were isolated and electrically stimulated to contract at 0.5 Hz. Mechanical and intracellular Ca$^{2+}$ properties were evaluated using an lonoptix Myocam$^{®}$ system. Contractile properties analyzed included peak shortening (PS), time-PS, time-to-90% relengthening, maximal velocities of shortening and relengthening (±dL/dt), change of electrically stimulated intracellular Ca$^{2+}$ fura-2 fluorescent intensity, and intracellular Ca$^{2+}$ decay. Our results indicated that short-term incubation of HNE (10$^{−6}$ to 10$^{−4}$ M) with myocyates depressed PS, ±dL/dt, and fura-2 fluorescent intensity; shortended time-PS; and elevated resting intracellular Ca$^{2+}$ levels without affecting time-to-90% relengthening and intracellular Ca$^{2+}$ decay. Interestingly, the NHE-induced cardiac mechanical effects (with the exception of shortened time-PS) were abolished by either the aldehyde dehydrogenase inhibitor cyanamide or the p38 mitogen-activated protein kinase inhibitor SB20350. These findings reveal a possible role of HNE in the lipid peroxidation-associated cardiac contractile dysfunction that is likely mediated through HNE metabolism and mitogen-activated protein kinase activation.
Starting Page	21
Ending Page	28
Page Count	8
File Format	PDF
ISSN	15307905
Journal	Cardiovascular Toxicology
Volume Number	4
Issue Number	1
e-ISSN	15590259
Language	English
Publisher	Humana Press
Publisher Date	2004-01-01
Publisher Place	Totowa
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	4-Hydroxy-trans-2-nonenal myocyte shortening intracellular Ca$^{2+}$ aldehyde dehydrogenase p38 MAP kinase Pharmacology/Toxicology Cardiology
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Toxicology Cardiology and Cardiovascular Medicine

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Inhibition of cardiac myocyte contraction by 4-hydroxy-trans-2-nonenal

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Inhibition of cardiac myocyte contraction by 4-hydroxy-trans-2-nonenal

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Inhibition of cardiac myocyte contraction by 4-hydroxy-trans-2-nonenal

The oxygen radical generator pyrogallol impairs cardiomyocyte contractile function via a superoxide and p38 MAP kinase-dependent pathway : Protection by anisodamine and tetramethylpyrazine

CXCR4 Receptor Antagonist Blocks Cardiac Myocyte P38 MAP Kinase Phosphorylation by HIV gp120

Nitrate-based vasodilators inhibit multiple vascular aldehyde dehydrogenases

Apoptotic Cell Death in Cultured Cardiomyocytes Following Exposure to Low Concentrations of 4-Hydroxy-2-nonenal

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Inhibition of cardiac myocyte contraction by 4-hydroxy-trans-2-nonenal