NDLI: Amelioration of Cardiac Remodeling in Congestive Heart Failure by β-Adrenoceptor Blockade is Associated with Depression in Sympathetic Activity

Please wait, while we are loading the content...

Arsenic-Induced QT Dispersion is Associated with Atherosclerotic Diseases and Predicts Long-Term Cardiovascular Mortality in Subjects with Previous Exposure to Arsenic: A 17-Year Follow-Up Study

Nanoparticle Inhalation Impairs Coronary Microvascular Reactivity via a Local Reactive Oxygen Species-Dependent Mechanism

In Utero Exposure of Female CD-1 Mice to AZT and/or 3TC: I. Persistence of Microscopic Lesions in Cardiac Tissue

Nitrogen Compounds Prevent H9c2 Myoblast Oxidative Stress-Induced Mitochondrial Dysfunction and Cell Death

The Effect of Saffron Consumption on Biochemical and Histopathological Heart Indices of Rats with Myocardial Infarction

Erratum to: Antiarrhythmic Effects of Some Antioxidant Vitamins in Rats Injected with Epinephrine

Cardiovascular Toxicology : Volume 9

Cardiovascular Toxicology : Volume 8

Cardiovascular Toxicology : Volume 7

Cardiovascular Toxicology : Volume 6

Cardiovascular Toxicology : Volume 5

Cardiovascular Toxicology : Volume 4

Cardiovascular Toxicology : Volume 3

Cardiovascular Toxicology : Volume 2

Cardiovascular Toxicology : Volume 1

Amelioration of Cardiac Remodeling in Congestive Heart Failure by β-Adrenoceptor Blockade is Associated with Depression in Sympathetic Activity

Content Provider	Springer Nature Link
Author	Machackova, Jarmila Sanganalmath, Santosh K. Barta, Judit Dhalla, Ken S. Dhalla, Naranjan S.
Copyright Year	2009
Abstract	This study investigated whether improvement in cardiac function and attenuation of cardiac remodeling by some β-adrenoceptor (β-AR) antagonists were associated with a depression in sympathetic activity in congestive heart failure (CHF) due to myocardial infarction (MI). Although cardiac dysfunction, hypertrophy and dilatation as well as increased plasma level of catecholamines are known to occur in CHF, the relationship between these parameters is poorly understood. Three weeks after occlusion of the coronary artery, rats were treated daily with 20 and 75 mg/kg of either atenolol or propranolol for 5 weeks. Sham-operated rats served as controls. Both atenolol and propranolol at 20 and 75 mg/kg doses attenuated the MI-induced cardiac hypertrophy, increases in left ventricular (LV) end-diastolic pressure, LV end-systolic volume and LV end-diastolic volume as well as depressions in LV systolic pressure, LV fractional shortening and cardiac output. PR interval was decreased and QT$_{c}$ interval was increased in CHF; these alterations were ameliorated by both atenolol and propranolol. The increased level of plasma epinephrine in CHF was also depressed by both low and high doses of atenolol and propranolol whereas the increased level of plasma norepinephrine was reduced by high but not low doses of these drugs. The results indicate that the beneficial effects of β-AR antagonists on cardiac remodeling and heart dysfunction in CHF may be due to the blockade of β-ARs in the myocardium and a depression in the sympathetic activity.
Starting Page	9
Ending Page	16
Page Count	8
File Format	PDF
ISSN	15307905
Journal	Cardiovascular Toxicology
Volume Number	10
Issue Number	1
e-ISSN	15590259
Language	English
Publisher	Humana Press Inc
Publisher Date	2009-12-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cardiac dysfunction Plasma catecholamines β-Adrenoceptor antagonists Cardiac hypertrophy and failure Cardiology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Toxicology Cardiology and Cardiovascular Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Reduction by β-adrenoceptor blockade of hypoxia-induced right heart hypertrophy in the rat

Beta-adrenoceptor signaling pathways mediate cardiac pathological remodeling.

Contrary microRNA Expression Pattern Between Fetal and Adult Cardiac Remodeling: Therapeutic Value for Heart Failure

Role of β-Adrenoceptor Desensitization in Heart Failure

Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies.

Additive effects of spironolactone and candesartan on cardiac sympathetic nerve activity and left ventricular remodeling in patients with congestive heart failure.

Cardiac Sympathetic Afferent Denervation Attenuates Cardiac Remodeling and Improves Cardiovascular Dysfunction in Rats With Heart Failure

Effect of Ketanserin on Hemodynamics, Plasma-Catecholamine Concentrations, and Serotonin Uptake by Platelets in Volunteers and Patients with Congestive Heart Failure

Editorial: Non-coding RNAs in heart failure

Amelioration of Cardiac Remodeling in Congestive Heart Failure by β-Adrenoceptor Blockade is Associated with Depression in Sympathetic Activity

Similar Documents

Reduction by β-adrenoceptor blockade of hypoxia-induced right heart hypertrophy in the rat

Beta-adrenoceptor signaling pathways mediate cardiac pathological remodeling.

Contrary microRNA Expression Pattern Between Fetal and Adult Cardiac Remodeling: Therapeutic Value for Heart Failure

Role of β-Adrenoceptor Desensitization in Heart Failure

Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies.

Additive effects of spironolactone and candesartan on cardiac sympathetic nerve activity and left ventricular remodeling in patients with congestive heart failure.

Cardiac Sympathetic Afferent Denervation Attenuates Cardiac Remodeling and Improves Cardiovascular Dysfunction in Rats With Heart Failure

Effect of Ketanserin on Hemodynamics, Plasma-Catecholamine Concentrations, and Serotonin Uptake by Platelets in Volunteers and Patients with Congestive Heart Failure

Editorial: Non-coding RNAs in heart failure

Amelioration of Cardiac Remodeling in Congestive Heart Failure by β-Adrenoceptor Blockade is Associated with Depression in Sympathetic Activity