NDLI: Beta-adrenoceptor signaling pathways mediate cardiac pathological remodeling.

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Beta-adrenoceptor signaling pathways mediate cardiac pathological remodeling.

Content Provider	Semantic Scholar
Author	Fu, Yongnan Xiao, Han Zhang, Y. Jonathan
Copyright Year	2012
Abstract	Beta-adrenoceptors (ARs), members of the G protein-coupled receptor (GPCR) superfamily, play a key role in the rapid regulation of myocardial function. Meanwhile, chronic catecholamine stimulation of adrenoceptors has been proved to be involved in the adverse myocardial remodeling, including cardiac hypertrophy, fibrosis, and apoptosis, which finally develop into heart failure. In the clinical situation, sympathetic hyperactivity is a key factor in the development of heart failure, and beta-blockers greatly improve the outcome of the disease. However, heart failure is still one of the leading causes of death. Therefore, a full understanding of the mechanism of beta-AR-mediated cardiac remodeling could indicate more targets for treating heart failure. This review summarizes a number of important signaling pathways involved in the process of cardiac pathological remodeling under chronic adrenergic stimulation.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.bioscience.org/fbs/getfile.php?FileName=/2012/v4e/af/484/484.pdf
PubMed reference number	22201979v1
Volume Number	4
Journal	Frontiers in bioscience
Language	English
Access Restriction	Open
Subject Keyword	Adrenergic Receptor Adrenergic beta-Antagonists Apoptosis Cardiac Hypertrophy Catecholamines Cessation of life Fibrosis Heart failure Hyperactive behavior
Content Type	Text
Resource Type	Article

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