NDLI: Interchromatin granule clusters of mouse preovulatory oocytes: Organization, molecular composition, and possible functions

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Cell and Tissue Biology : Volume 4, Issue 1, February 2010

Cell and Tissue Biology : Volume 3

Cell and Tissue Biology : Volume 2

Cell and Tissue Biology : Volume 1

Interchromatin granule clusters of mouse preovulatory oocytes: Organization, molecular composition, and possible functions

Content Provider	Springer Nature Link
Author	Pochukalina, G. N. Bogolyubov, D. S. Parfev, V. N.
Copyright Year	2010
Abstract	The nuclei of mouse oocytes at the late diplotene stage of meiotic prophase I contain numerous interchromatin granule clusters (IGCs), which are universal, evolutionarily conserved nuclear compartments that are specifically enriched in factors of pre-mRNA splicing. In keeping with the current concepts, IGCs may play an important role in the processes of gene expression by the coupling interconnection of its individual stages, ranging from the transcription to export of mRNA. We have obtained data on the distribution of poly(A)$^{+}$ RNA, heterogenous nuclear ribonucleoprotein (hnRNP) proteins of the A/B family, and the NXF1/TAP factor of mRNA export in association with IGCs of mouse preovulatory oocytes. In the presented work, using the inhibitor of phosphatases okadaic acid, we have managed to demonstrate the dynamics of large IGCs under the conditions of specific phosphorylation of SR proteins for the first time. The studies were carried out using microinjections of oligonucleotide probes into oocytes, as well as confocal laser scanning and electron microscopy. The problem of the functional significance of IGCs in processes of pre-mRNA metabolism, as well as the participation of IGCs in the organization of mRNA export from the nucleus into the cytoplasm are discussed.
Starting Page	167
Ending Page	176
Page Count	10
File Format	PDF
ISSN	1990519X
Journal	Cell and Tissue Biology
Volume Number	4
Issue Number	2
e-ISSN	19905203
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2010-05-09
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	mouse oocyte nucleus nuclear compartments interchromatin granule clusters metabolism of pre-mRNA poly(A)$^{+}$ RNA export of mRNA okadaic acid electron microscopy confocal microscopy Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology

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