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| Content Provider | Springer Nature Link |
|---|---|
| Author | Shpakov, A. O. Bondareva, V. M. Chistyakova, O. V. |
| Copyright Year | 2010 |
| Abstract | Type-1 diabetes mellitus (DM) leads to numerous disturbances in the male and female reproductive systems. As was shown previously, one of the main causes of the development of complications in DM is a change in the sensitivity of the adenylyl cyclase signaling system (ACSS) to hormones. The aim of this work consisted in detection of disturbances in the hormone-regulated ACSS in reproductive system of rats with experimental type-1 DM (EDM1) caused by administration of streptozotocin. It has been shown that, in the testes of male rats with 5-day-long EDM1 the stimulating effects of human chorionic gonadotropin (HCG) and PACAP-38 on adenylyl cyclase (AC) and the GTP binding of G proteins are decreased considerably. In the uteri of female rats with EDM1 the effects of relaxin, PACAP-38, and biogenic amines are markedly decreased, whereas in ovaries only the effects of HCG are decreased. In all studied tissues of rats with EDM1 the attenuation of somatostatin inhibitory effects was observed, while in the uterus the inhibitory effects of serotonin and adrenalin were also decreased. Thus, in the reproductive tissues of rats with EDM1, the hormone regulatory effects on ACSS are decreased, especially the effect of HCG and the hormones, AC-inhibitors. We believe that the sensitivity of ACSS to hormones in EDM1 underlies the development of pathological changes in the reproductive system of diabetic rats under the conditions of hyperglycemia and insulin deficiency characteristic of type-1 DM. |
| Starting Page | 208 |
| Ending Page | 214 |
| Page Count | 7 |
| File Format | |
| ISSN | 1990519X |
| Journal | Cell and Tissue Biology |
| Volume Number | 4 |
| Issue Number | 2 |
| e-ISSN | 19905203 |
| Language | English |
| Publisher | SP MAIK Nauka/Interperiodica |
| Publisher Date | 2010-05-09 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | adenylyl cyclase G protein diabetes uterus somatostatin testes chorionic gonadotropin ovary PACAP Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology |
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