NDLI: Hpyerglycemic effect of a mixture of sea cucumber and cordyceps sinensis in streptozotocin-induced diabetic rat

Content Provider	Springer Nature Link
Author	Hu, Shiwei Wang, Jingfeng Li, Zhaojie Fu, Jia Wang, Yuming Xue, Changhu
Copyright Year	2014
Abstract	Sea cucumber and cordyceps sinensis are used as both food and traditional medicines in Asia. This study was carried out in order to investigate the hpyerglycemic effect of a mixture of sea cucumber (Apostichopus japonicas) and cordyceps sinensis (Cordyceps militaris) (SCC) in diabetic rat and explore the mechanism underlining such an effect. The diabetic model rat was induced with intraperitoneal injection of streptozotocin (STZ). The diabetic model rats were randomly divided into control group (0.9% NaCl), low dose group (300 mg SCC·(kg body weight)$^{−1}$) and high dose group (1200 mg SCC (kg body weight)$^{−1}$). Sodium chloride and SCC were intragastrically administered once a day for 35 d. Changes in fasting serum glucose and serum insulin content, oral glucose tolerance and liver and muscle glycogen content were routinely evaluated. Pancreas tissue and β-cells of islets were observed under both optical and transmission electronic microscope, respectively. The abundance of glucose metabolism-relating genes in gastrocnemius and epididymal adipose tissue was determined with either reverse transcription PCR (RT-PCR) or western blotting. Results showed that SCC significantly decreased fasting serum glucose content, improved glucose tolerance and increased serum insulin and glycogen content; repaired STZ-injured β-cells of diabetic rat, and increased the expression of phosphatidylinositol 3 kinase (PI(3)K), protein kinase B (PKB) and glucose transporter 4 (Glut4) encoding protein in both gastrocnemius and adipose tissue, and Glut4 encoding gene in peripheral tissue. Our findings demonstrated that SCC exerted an anti-hyperglycemic effect by repairing β-cells and promoting insulin-mediated signal transduction pathway in insulin-sensitive gastrocnemius and adipose tissue.
Starting Page	271
Ending Page	277
Page Count	7
File Format	PDF
ISSN	16725182
Journal	Journal of Ocean University of China
Volume Number	13
Issue Number	2
e-ISSN	19935021
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-11-08
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	sea cucumber cordyceps sinensis hpyerglycemic effect β-cell glucose transporter 4 phosphatidylinositol 3-kinase Oceanography Meteorology
Content Type	Text
Resource Type	Article
Subject	Oceanography Ocean Engineering

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