NDLI: Purified Canola Lutein Selectively Inhibits Specific Isoforms of Mammalian DNA Polymerases and Reduces Inflammatory Response

Content Provider	Springer Nature Link
Author	Horie, Sho Okuda, Chiaki Yamashita, Takatoshi Watanabe, Kenichi Kuramochi, Kouji Hosokawa, Masashi Takeuchi, Toshifumi Kakuda, Makiko Miyashita, Kazuo Sugawara, Fumio Yoshida, Hiromi Mizushina, Yoshiyuki
Copyright Year	2010
Abstract	In the screening of DNA polymerase (pol) inhibitor, we isolated lutein, a carotenoid, from the crude (unrefined) pressed oil of canola (low erucic acid rapeseed, Brassica napus L.). Commercially prepared carotenoids such as lutein (1), zeaxanthin (2), β-cryptoxanthin (3), astaxanthin (4), canthaxanthin (5), β-carotene (6), lycopene (7), capsanthin (8), fucoxanthin (9) and fucoxanthinol (10), were investigated for the inhibitory activities of pols. Compounds 1, 2 and 8 exhibited strong inhibition of the activities of mammalian pols β and λ, which are DNA repair- and/or recombination-related pols. On the other hand, all carotenoids tested had no influence on the activity of a mammalian pol α, which is a DNA replicative pol. Lutein (1) was the strongest pol inhibitor of mammalian pols β and λ in the prepared ten carotenoids tested, but did not influence of the activities of mammalian pols α, γ, δ and ε. The tendency for pols β and λ inhibition by these carotenoids showed a positive correlation with the suppression of TPA (12-O-tetradecanoylphorbol-13-acetate)-induced inflammation. These results suggest that cold pressed unrefined canola/rapeseed oil, or other oils with high levels of lutein and other carotenoids, may be useful for their anti-inflammatory properties.
Starting Page	713
Ending Page	721
Page Count	9
File Format	PDF
ISSN	00244201
Journal	Lipids
Volume Number	45
Issue Number	8
e-ISSN	15589307
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-07-29
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lutein Carotenoids Canola/rapeseed Industrial waste DNA polymerase (pol) Enzyme inhibitor Anti-inflammation Structure and bioactivity relationship Microbial Genetics and Genomics Medicinal Chemistry Nutrition Medical Biochemistry Neurochemistry Lipidology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Organic Chemistry Biochemistry

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