NDLI: Effect of sesamin on mitochondrial and peroxisomal β-oxidation of arachidonic and eicosapentaenoic acids in rat liver

Content Provider	Springer Nature Link
Author	Umeda Sawada, Rumi Ogawa, Megumi Nakamura, Mayumi Igarashi, Osamu
Copyright Year	2001
Abstract	The effects of dietary sesamin on the hepatic metabolism of arachidonic (AA) and eicosapentaenoic (EPA) acids, were investigated with respect to their β-oxidation and secretion as triacylglycerol (TG). For 2 wk, rats were fed three types of dietary oils: (i) corn oil (control) group; (ii) FPA group: FPA ethyl esters/rapeseed oil=2∶3; (iii) AA group: AA ethyl esters/palm oil/perilla oil=2∶2∶1, with or without 0.5% (w/w) of sesamin. Dietary sesamin significantly increased the activities of hepatic mitochondrial and peroxisomal fatty acid oxidation enzymes (mitochondrial carnitine acyltransferase I, acyl-CoA dehydrogenase, and peroxisomal acyl-CoA oxidase). Dietary FPA increased mitochondrial carnitine acyltransferase I and peroxisomal acyl-CoA oxidase. Dietary AA, however, had an effect on peroxisomal acyl-CoA oxidase only. In whole liver and the TG fraction, EPA and AA concentrations were significantly increased by dietary EPA and AA, respectively, and were decreased by dietary sesamin. In hepatic mitochondria and peroxisomes, EPA concentration was increased by dietary EPA, but AA was not changed by dietary AA. The addition of dietary sesamin to the EPA-supplemented diet significantly decreased the EPA concentration compared to concentrations found with consumption of dietary EPA alone. These results suggest that sesamin increased β-oxidation enzyme activities and reduced hepatic EPA and AA concentrations by degradation. The stimulating effect of sesamin on β-oxidation, however, was more significant in the EPA group than in the AA group. Hepatic AA concentration was altered by the joint effect of sesamin through esterification into TG and the stimulation of β-oxidation.
Starting Page	483
Ending Page	489
Page Count	7
File Format	PDF
ISSN	00244201
Journal	Lipids
Volume Number	36
Issue Number	5
e-ISSN	15589307
Language	English
Publisher	Springer-Verlag
Publisher Date	2001-01-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Nutrition Bioorganic Chemistry Medicinal Chemistry Medical Biochemistry Biochemistry Microbial Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Organic Chemistry Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Eicosapentaenoic and docosahexaenoic acid affect mitochondrial and peroxisomal fatty acid oxidation in relation to substrate preference

Eicosapentaenoic acid, but not oleic acid, stimulates β-oxidation in adipocytes

Comparative effects of α- and γ-linolenic acids on rat liver fatty acid oxidation

Arachidonic, eicosapentaenoic, and biosynthetically related fatty acids in the seed lipids from a primitive gymnosperm, Agathis robusta

The metabolism and n−6/n−3 ratio of essential fatty acids in rats: Effect of dietary arachidonic acid and a mixture of sesame lignans (sesamin and episesamin)

Effects of eicosapentaenoic and docosahexaenoic acids dietary supplementation on cell proliferation and apoptosis in rat colonic mucosa

Suspicion of latent Δ5-desaturase and peroxisomal β-oxidation deficiency in elderly women over 75 years of age

The effect of highly purified eicosapentaenoic and docosahexaenoic acids on monocyte phagocytosis in man

Thioglycolate-elicited rat macrophages exhibit alterations in incroporation and oxidation of fatty acids

Effect of sesamin on mitochondrial and peroxisomal β-oxidation of arachidonic and eicosapentaenoic acids in rat liver

Similar Documents

Eicosapentaenoic and docosahexaenoic acid affect mitochondrial and peroxisomal fatty acid oxidation in relation to substrate preference

Eicosapentaenoic acid, but not oleic acid, stimulates β-oxidation in adipocytes

Comparative effects of α- and γ-linolenic acids on rat liver fatty acid oxidation

Arachidonic, eicosapentaenoic, and biosynthetically related fatty acids in the seed lipids from a primitive gymnosperm, Agathis robusta

The metabolism and n−6/n−3 ratio of essential fatty acids in rats: Effect of dietary arachidonic acid and a mixture of sesame lignans (sesamin and episesamin)

Effects of eicosapentaenoic and docosahexaenoic acids dietary supplementation on cell proliferation and apoptosis in rat colonic mucosa

Suspicion of latent Δ5-desaturase and peroxisomal β-oxidation deficiency in elderly women over 75 years of age

The effect of highly purified eicosapentaenoic and docosahexaenoic acids on monocyte phagocytosis in man

Thioglycolate-elicited rat macrophages exhibit alterations in incroporation and oxidation of fatty acids

Effect of sesamin on mitochondrial and peroxisomal β-oxidation of arachidonic and eicosapentaenoic acids in rat liver