NDLI: Correlation of fatty acid unsaturation of the major liver mitochondrial phospholipid classes in mammals to their maximum life span potential

Content Provider	Springer Nature Link
Author	Portero Otín, Manuel Josep Bellumunt, Maria Cristina Ruiz, Maria Barja, Gustavo Pamplona, Reinald
Copyright Year	2001
Abstract	Free radical damage is considered a determinant factor in the rate of aging. Unsaturated fatty acids are the tissue macromolecules that are most sensitive to oxidative damage. Therefore, the presence of low proportions of fatty acid unsaturation is exprected in the tissues of long-lived animals. Accordingly, the fatty acid compositions of the major liver mitochondrial phospholipid classes from eight mammals, ranging in maximum life span potential (MLSP) from 3.5 to 46 yr, show that the total number of double bonds is inversely correlated with MLSP in both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (r=0.757, P<0.03, and r=0.862, P<0.006, respectively), but not in cardiolipin (P=0.323). This is due not to a low content of unsaturated fatty acids in long-lived animals, but mainly to a redistribution between kinds of fatty acids on PtdCho and PtdEtn, shifting from arachidonic (r=0.911, P<0.002, and r=0.681, P=0.05, respectively), docosahexaenoic (r=0.931 and r=0.965, P<0.0001, respectively) and palmitic (r=0.944 and r=0.974, P<0.0001, respectively) acids to linoleic acid (r=0.942, P<0.0001, for PtdCho; and r=0.957, P<0.0001, for PtdEtn). For cardiolipin, only arachidonic acid showed a significantly inverse correlation with MLSP (r=0.904, P<0.002). This pattern strongly suggests the presence of a species-specific desaturation pathway and deacylation-reacylation cycle in determining the mitochondrial membrane composition, maintaining a low degree of fatty acid unsaturation in long-lived animals.
Starting Page	491
Ending Page	498
Page Count	8
File Format	PDF
ISSN	00244201
Journal	Lipids
Volume Number	36
Issue Number	5
e-ISSN	15589307
Language	English
Publisher	Springer-Verlag
Publisher Date	2001-01-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Nutrition Bioorganic Chemistry Medicinal Chemistry Medical Biochemistry Biochemistry Microbial Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Organic Chemistry Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Changes in liver fatty acid unsaturation after partial hepatectomy in the rat

Liver and intestinal fatty acid-binding protein expression increases phospholipid content and alters phospholipid fatty acid composition in L-cell fibroblasts

Remodeling of phospholipid fatty acids in mitochondrial membranes of estivating snails

Fatty acid chain length and degree of unsaturation are inversely associated with serum triglycerides

Erucic Acid is Differentially Taken up and Metabolized in Rat Liver and Heart

Phospholipid fatty acid composition in type I and type II rat muscle

Effects of fructose and troglitazone on phospholipid fatty acid composition in rat skeletal muscle

Blood phospholipid fatty acid analysis of adults with and without attention deficit/hyperactivity disorder

Dietary fish oil dose- and time-response effects on cardiac phospholipid fatty acid composition

Correlation of fatty acid unsaturation of the major liver mitochondrial phospholipid classes in mammals to their maximum life span potential

Similar Documents

Changes in liver fatty acid unsaturation after partial hepatectomy in the rat

Liver and intestinal fatty acid-binding protein expression increases phospholipid content and alters phospholipid fatty acid composition in L-cell fibroblasts

Remodeling of phospholipid fatty acids in mitochondrial membranes of estivating snails

Fatty acid chain length and degree of unsaturation are inversely associated with serum triglycerides

Erucic Acid is Differentially Taken up and Metabolized in Rat Liver and Heart

Phospholipid fatty acid composition in type I and type II rat muscle

Effects of fructose and troglitazone on phospholipid fatty acid composition in rat skeletal muscle

Blood phospholipid fatty acid analysis of adults with and without attention deficit/hyperactivity disorder

Dietary fish oil dose- and time-response effects on cardiac phospholipid fatty acid composition

Correlation of fatty acid unsaturation of the major liver mitochondrial phospholipid classes in mammals to their maximum life span potential