NDLI: Recruitment and Stabilization of Brain Activation Within a Working Memory Task; an fMRI Study

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Disturbed Functional Connectivity of Cortical Activation during Semantic Discrimination in Patients with Schizophrenia and Subjects at Genetic High-risk

Brain Imaging and Behavior : Volume 3

Brain Imaging and Behavior : Volume 2

Brain Imaging and Behavior : Volume 1

Recruitment and Stabilization of Brain Activation Within a Working Memory Task; an fMRI Study

Content Provider	Springer Nature Link
Author	Paskavitz, James F. Sweet, Lawrence H. Wellen, Jeremy Helmer, Karl G. Rao, Stephen M. Cohen, Ronald A.
Copyright Year	2009
Abstract	Seventeen subjects underwent functional magnetic resonance imaging (fMRI) performing a 2-Back verbal working memory (VWM) task alternating with a control task to characterize the temporal dynamics of the specific brain regions involved in VWM. Serial sampling of 2-Back sub-blocks revealed many small areas of activation that grew and merged over time. Significant temporal effects for volume recruitment were seen in specific brain regions known to be involved in VWM, including the bilateral dorsolateral prefrontal (DLPFC), medial frontal (MFC), posterior parietal (PPC) cortices and also some extra-cortical and subcortical regions of interest (ROIs). Signal intensity increased over time in most ROIs recruited early in the task, including the DLPFC, MFC, and PPC but excluding dorsal premotor areas. MFC intensity increased rapidly then stabilized with time. The uniqueness of the MFC response raises the possibility that it drives the recruitment process. Increases in intensity and volume were associated with worsening VWM performance over time, suggesting that recruitment of brain resources is necessary in attempting to sustain difficult tasks. Worsening of performance over sub-blocks despite stable task demands reinforces this temporal “load effect”.
Starting Page	5
Ending Page	21
Page Count	17
File Format	PDF
ISSN	19317557
Journal	Brain Imaging and Behavior
Volume Number	4
Issue Number	1
e-ISSN	19317565
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-12-11
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	fMRI Verbal working memory Temporal dynamics Recruitment Health Psychology Child and School Psychology Clinical Psychology Cognitive Psychology Neuropsychology Public Health/Gesundheitswesen
Content Type	Text
Resource Type	Article
Subject	Neurology Radiology, Nuclear Medicine and Imaging Cognitive Neuroscience Behavioral Neuroscience Neurology (clinical) Cellular and Molecular Neuroscience Psychiatry and Mental Health

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