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Disturbed Functional Connectivity of Cortical Activation during Semantic Discrimination in Patients with Schizophrenia and Subjects at Genetic High-risk

Brain Imaging and Behavior : Volume 3

Brain Imaging and Behavior : Volume 2

Brain Imaging and Behavior : Volume 1

Comparison of Manual and Automated Determination of Hippocampal Volumes in MCI and Early AD

Content Provider	Springer Nature Link
Author	Shen, Li Saykin, Andrew J. Kim, Sungeun Firpi, Hiram A. West, John D. Risacher, Shann L. McDonald, Brenna C. McHugh, Tara L. Wishart, Heather A. Flashman, Laura A.
Copyright Year	2010
Abstract	MRI-based hippocampal volume analysis has been extensively employed given its potential as a biomarker for brain disorders such as Alzheimer’s disease (AD), and accurate and efficient determination of hippocampal volumes from brain images is still a challenging issue. We compared an automated method, FreeSurfer (V4), with a published manual protocol for the determination of hippocampal volumes from T1-weighted MRI scans. Our study included MRI data from 125 older adult subjects: healthy controls with no significant cognitive complaints or deficits (HC, n = 38), euthymic individuals with cognitive complaints (CC, n = 39) but intact neuropsychological performance, and patients with amnestic mild cognitive impairment (MCI, n = 37) or a clinical diagnosis of probable AD (AD, n = 11). Pearson correlations and intraclass correlation coefficients (ICCs) were calculated to evaluate the relationship between results of the manual tracing and FreeSurfer methods and to estimate their agreement. Results indicated that these two methods derived highly correlated results with strong agreement. After controlling for the age, sex and intracranial volume in statistical group analysis, both the manual tracing and FreeSurfer methods yield similar patterns: both the MCI group and the AD group showed hippocampal volume reduction compared to both the HC group and the CC group, and the HC and CC groups did not differ. These comparisons suggest that FreeSurfer has the potential to be used in automated determination of hippocampal volumes for large-scale MCI/AD-related MRI studies, where manual methods are inefficient or not feasible.
Starting Page	86
Ending Page	95
Page Count	10
File Format	PDF
ISSN	19317557
Journal	Brain Imaging and Behavior
Volume Number	4
Issue Number	1
e-ISSN	19317565
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-02-13
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Magnetic resonance imaging Segmentation Hippocampus Cognitive complaints Mild cognitive impairment Alzheimer’s disease Health Psychology Child and School Psychology Clinical Psychology Cognitive Psychology Neuropsychology Public Health/Gesundheitswesen
Content Type	Text
Resource Type	Article
Subject	Neurology Radiology, Nuclear Medicine and Imaging Cognitive Neuroscience Behavioral Neuroscience Neurology (clinical) Cellular and Molecular Neuroscience Psychiatry and Mental Health

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Comparison of Manual and Automated Determination of Hippocampal Volumes in MCI and Early AD

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