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Disturbed Functional Connectivity of Cortical Activation during Semantic Discrimination in Patients with Schizophrenia and Subjects at Genetic High-risk

Brain Imaging and Behavior : Volume 3

Brain Imaging and Behavior : Volume 2

Brain Imaging and Behavior : Volume 1

Disturbed Functional Connectivity of Cortical Activation during Semantic Discrimination in Patients with Schizophrenia and Subjects at Genetic High-risk

Content Provider	Springer Nature Link
Author	Li, Xiaobo Branch, Craig A. Nierenberg, Jay DeLisi, Lynn E.
Copyright Year	2010
Abstract	Schizophrenia has a strong genetic component that is relevant to the understanding of the pathophysiology of the syndrome. Thus, recent investigations have shifted from studies of diagnosed patients with schizophrenia to examining their unaffected relatives. Previous studies found that during language processing, relatives thought to be at genetic high-risk for the disorder exhibit aberrant functional activation in regions of language processing, specifically in the left inferior frontal gyrus (Broca’s area). However, functional connectivity among the regions involved in language pathways is not well understood. In this study, we examined the functional connectivity between a seed located in Broca’s area and the remainder of the brain during a visual lexical decision task, in 20 schizophrenia patients, 21 subjects at genetic high risk for the disorder and 21 healthy controls. Both the high-risk subjects and patients showed significantly reduced activation correlations between seed and regions related to visual language processing. Compared to the high-risk subjects, the schizophrenia patients showed even fewer regions that were correlated with the seed regions. These results suggest that there is aberrant functional connectivity within cortical language circuitry in high-risk subjects and patients with schizophrenia. Broca’s area, which is one of the important regions for language processing in healthy controls, had a significantly reduced role in the high-risk subjects and patients with schizophrenia. Our findings are consistent with the existence of an underlying biological disturbance that begins in genetically at risk individuals and progresses to a greater extent in those who eventually develop schizophrenia.
Starting Page	109
Ending Page	120
Page Count	12
File Format	PDF
ISSN	19317557
Journal	Brain Imaging and Behavior
Volume Number	4
Issue Number	1
e-ISSN	19317565
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-02-17
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Schizophrenia Genetic high-risk Semantic discrimination task fMRI Functional connectivity Health Psychology Child and School Psychology Clinical Psychology Cognitive Psychology Neuropsychology Public Health/Gesundheitswesen
Content Type	Text
Resource Type	Article
Subject	Neurology Radiology, Nuclear Medicine and Imaging Cognitive Neuroscience Behavioral Neuroscience Neurology (clinical) Cellular and Molecular Neuroscience Psychiatry and Mental Health

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