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| Content Provider | Springer Nature Link |
|---|---|
| Author | Li, Xiao Jin, Ningyi Lian, Hai Guan, Goufang Sun, Lili Li, Xuemei Zheng, Hongling |
| Copyright Year | 2006 |
| Abstract | Hemagglutinin-neuramidinase (HN), a Newcastle disease virus-derived protein, not only mediates receptor recognition but also possesses neuraminidase (NA) activity, the ability to cleave a component of those receptors, N-acetylneuraminic acid (NAcneu, sialic acid). It is known that this protein in mammalian species, including human beings, has interesting anti-neoplastic as well as immune stimulating properties. To explore the use of the HN gene in cancer gene therapy, we constructed a recombinant fowlpox virus expressing the HN protein (vFV-HN) and compared the anti-tumor activity of the recombinant virus with that of wild-type fowlpox virus (FPV) in vivo and in vitro. Here we found that although B16 cells were somewhat resistant to the basal cytotoxic effect of wild-type fowlpox virus, infection with vFV-HN caused a pronounced cytotoxic effect and, the survival of tumor-bearing mice immunized with vFV-HN was significantly increased compared with the survival of mice immunized with the FPV alone. Furthermore, the immunization of mice with vFV-HN elicited a B16 tumor-specific cytotoxic T lymphocyte (CTL) response and clonal expansion of both CD4+ and CD8+ T cell populations in vivo. In addition, T cells from lymph nodes of mice vaccinated with vFV-HN secreted high levels of the Th1 cytokine IL-2 and IFN-γ, indicating that the regression of tumor cells is related to a Th1-type dominant immune response. These results demonstrate that vaccination with vFV-HN may be a potential strategy for cancer gene therapy. |
| Starting Page | 2724 |
| Ending Page | 2730 |
| Page Count | 7 |
| File Format | |
| ISSN | 10016538 |
| Journal | Chinese Science Bulletin |
| Volume Number | 51 |
| Issue Number | 22 |
| e-ISSN | 18619541 |
| Language | English |
| Publisher | Science in China Press |
| Publisher Date | 2006-01-01 |
| Publisher Place | Beijing |
| Access Restriction | Subscribed |
| Subject Keyword | NDV HN gene fowlpox virus vector anti-tumor Science Chemistry/Food Science Geosciences Life Sciences Physics Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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