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| Content Provider | Springer Nature Link |
|---|---|
| Author | He, Hualiang Zhou, Hui Xiao, Zhendong Zeng, Xianfen Chen, Junyu Zheng, Tao Qu, Lianghu |
| Copyright Year | 2006 |
| Abstract | Three novel small noncoding RNAs were identified from the conserved intronic regions of D. melanogaster by using comparative genomics method and molecular biology approach. One is a novel snoRNA in a combinated way, which displays structural features typical of C/D box snoRNA family and possesses a 10-nt-long rRNA antisense element for guiding the 2′-O-methylation of the D. melanogaster 28S rRNA at C2673. The other two are miRNAs whose predicted precursors adopt a stemloop structure characteristic of known miRNA. The two miRNAs genes appear to have ubiquitous expression profiles with ∼23-nt RNA transcripts detected by Northern blotting. Our study revealed 396 multi-species intronic conserved sequences (MCIS) that nested in the introns with a length from 100 to 500 bp. In addition to small RNA coding, the MCIS might function as cis-acting elements involved in gene transcription or post-transcriptional processing. |
| Starting Page | 2737 |
| Ending Page | 2742 |
| Page Count | 6 |
| File Format | |
| ISSN | 10016538 |
| Journal | Chinese Science Bulletin |
| Volume Number | 51 |
| Issue Number | 22 |
| e-ISSN | 18619541 |
| Language | English |
| Publisher | Science in China Press |
| Publisher Date | 2006-01-01 |
| Publisher Place | Beijing |
| Access Restriction | Subscribed |
| Subject Keyword | Drosophila melanogaster box C/D snoRNA miRNA intron MCIS Science Chemistry/Food Science Geosciences Life Sciences Physics Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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