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| Content Provider | Springer Nature Link |
|---|---|
| Author | Xian, Chengyu Wang, Yuanliang Zhang, Bingbing Tang, Liling Pan, Jun Luo, Yanfeng Jiang, Peng Li, Dajun |
| Copyright Year | 2006 |
| Abstract | Insulin-like growth factor 1 (IGF-1) promotes osteoblasts differentiation and bone formation, and its expression is induced by mechanical stretch, thus IGF-1 has been considered an effector molecule that links mechanical stimulation and local tissue responses. In this study, a mechanical stretching device was designed to apply physiological level static or cyclic stretching stimulation to osteoblasts. Different isoforms of IGF-1 mRNA were amplified by RT-PCR from the cells using respective primers and these amplified products were sequenced. An isoform of IGF-1 splicing product was found to be selectively produced by osteoblasts under stretching stimulation. This IGF-1 isoform had identical sequence with the mechano growth factor (MGF) which was originally identified in muscle cells. Regulations of the expression of the liver-type IGF (L.IGF-1) and MGF in osteoblasts under stretch stimulation were further studied using semi-quantitative RT-PCR. Stretch stimulation was found to promot the expression of IGF-1 (L.IGF-1 and MGF), and for both isoforms expression was more effectively stimulated by cyclic stretch than static stretch. MGF was detected only in osteoblasts subjected to mechanical stretch, suggesting MGF was a stretch sensitive growth factor. Expression of MGF peaked earlier than that of L.IGF-1, which was similar to their regulation in muscle and suggested similar roles of MGF and L.IGF-1 in bone as in muscle cells. The functions of MGF and L.IGF-1 in osteoblasts shall be established by further experimental studies. |
| Starting Page | 2731 |
| Ending Page | 2736 |
| Page Count | 6 |
| File Format | |
| ISSN | 10016538 |
| Journal | Chinese Science Bulletin |
| Volume Number | 51 |
| Issue Number | 22 |
| e-ISSN | 18619541 |
| Language | English |
| Publisher | Science in China Press |
| Publisher Date | 2006-01-01 |
| Publisher Place | Beijing |
| Access Restriction | Subscribed |
| Subject Keyword | insulin-like growth factor-1 (IGF-1) mechano growth factor (MGF) alternative splice osteoblasts stretching Science Chemistry/Food Science Geosciences Life Sciences Physics Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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