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| Content Provider | Springer Nature Link |
|---|---|
| Author | Jiang, Yanan Guo, Wei |
| Copyright Year | 2015 |
| Abstract | Solid-state nanopores are generally considered as an indispensable element in the research field of fundamental ion transport and molecular sensing. The improvement in fabrication and chemical modification of the solid-state nanopores remains increasingly updated. During the last decades, numerous works have been reported on the nanopore-based sensing applications. More and more new analytical methods using nanopore-based devices are emerging. In this review, we highlight the recent progress on the analytical methods for the interdisciplinary and fast-growing area of nanopore research. According to the different types of the electrical readout, whether it is steady-state ionic current or transient current fluctuation, the nanopore-based sensing and analysis can be generally divided into two categories. For the first type, the electrical readout shows a stable blockade or reopening of the nanopore conductance in the presence of target analytes, termed steady-state analysis, including the conductance change, electrochemical analysis, and two-dimensional scanning and imaging. The other type is based on the transient fluctuation in the transmembrane ionic current, termed transient-state analysis, including the noise analysis, transient ion transport, and transverse tunneling current. The investigation of solid-state nanopores for chemical sensing is just in its infancy. For further research work, not only new nanopore materials and chemical modifications are needed, but also other non-electric-based sensing techniques should be developed. We will focus our future research in the framework of bio-inspired, smart, multiscale interfacial materials and extend the spirit of binary cooperative complementary nanomaterials. |
| Starting Page | 491 |
| Ending Page | 502 |
| Page Count | 12 |
| File Format | |
| ISSN | 20959273 |
| Journal | Chinese Science Bulletin |
| Volume Number | 60 |
| Issue Number | 5 |
| e-ISSN | 20959281 |
| Language | English |
| Publisher | Science China Press |
| Publisher Date | 2015-02-11 |
| Publisher Place | Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Nanopore Sensing Stimuli response Steady state Transient signal Science Life Sciences Physics Chemistry/Food Science Earth Sciences Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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