NDLI: Pharmacologically active compounds in the Anoectochilus and Goodyera species

Content Provider	Springer Nature Link
Author	Du, Xiao Ming Iri, buto Furusho, rihiro Hayashi, Jun Shoyama, Yukihiro
Copyright Year	2008
Abstract	The extract of Anoectochilus formosanus showed significant activity in decreasing the levels of the cytosolic enzymes LDH, GOT, and GPT, and the result demonstrated that A. formosanus possessed prominent hepatoprotective activity against CCl$_{4}$-induced hepatotoxicity. Moreover, in the results of the test using aurothioglucose-induced obese mice, the extract showed a significant antihyperliposis effect. A. formosanus grown in the wild and propagated by tissue culture contain ten compounds, including a major known component, (3R)-3-(β-d-glucopyranosyloxy)butanolide (kinsenoside; 1), and two new components, (3R)-3-(β-d-glucopyranosyloxy)-4-hydroxybutanoic acid (2) and 2-[(β-d-glucopyranosyloxy)methyl]-5-hydroxymethylfuran (3), along with the known compounds, isopropyl-β-d-glucopyranoside (4), (R)-3,4-dihydroxybutanoic acid γ-lactone (5), 4-(β-d-glucopyranosyloxy) benzyl alcohol (6), (6R,9S)-9-(β-d-glucopyranosyloxy)megastigma-4,7-dien-3-one (7), and (3R)-3-(β-d-glucopyranosyloxy)-4-hydroxybutanolide (8). Since a higher concentration of kinsenoside (1) was detected in the crude drugs A. formosanus and A. koshunensis by high-performance liquid chromatography (HPLC) analysis, we proved a simple purification system for kinsenoside (1), giving 180 mg of kinsenoside (1) from 1 g of dried samples for further pharmacological experiments. In an anti-hyperliposis assay using high-fat-diet rats, 1 significantly reduced the weights of the body and the liver, and also decreased the triglyceride level in the liver compared to those of control rats. On the other hand, the epimer of 1, (3S)-3-(β-d-glucopyranosyloxy)butanolide, goodyeroside A (9), which was isolated from the Goodyera species, had no effect for anti-hyperliposis. In aurothioglucose-induced obese mice, 1 suppressed the body and liver weight increase, significantly ameliorated the triglyceride level in the liver, and also reduced the deposition of uterine fat pads. The anti-hepatoxic activities of 9 and goodyerosides B (10) were studied on injury induced by CCl$_{4}$ in primary cultured rat hepatocytes by measuring the levels of LDH, GOT, and GPT. In the CCl$_{4}$-treated control group, there were marked increases in LDH, GOT, and GPT activities compared with the normal group. In contrast, these levels were suppressed in 9- and 10-treated groups. Goodyerin (11), a new typical flavone glycoside, exhibited a significant and dose-dependent sedative and anticonvulsant effect.
Starting Page	132
Ending Page	148
Page Count	17
File Format	PDF
ISSN	13403443
Journal	Journal of Natural Medicines
Volume Number	62
Issue Number	2
e-ISSN	18610293
Language	English
Publisher	Springer Japan
Publisher Date	2008-01-18
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Orchidaceae Anoectochilus Goodyera Anti-hyperliposis Clinical trial Pharmacy Medicinal Chemistry Complementary & Alternative Medicine Plant Sciences Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Molecular Medicine Complementary and Alternative Medicine Pharmaceutical Science

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