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| Content Provider | Springer Nature Link |
|---|---|
| Author | Hiraki, Eri Furuta, Shoko Kuwahara, Rika Takemoto, Naomichi Nagata, Toshiro Akasaka, Taiki Shirouchi, Bungo Sato, Masao Ohnuki, Koichiro Shimizu, Kuniyoshi |
| Copyright Year | 2017 |
| Abstract | Hericium erinaceus (H. erinaceus) improves the symptoms of menopause. In this study, using ovariectomized mice as a model of menopause, we investigated the anti-obesity effect of this mushroom in menopause. Mice fed diets containing H. erinaceus powder showed significant decreases in the amounts of fat tissue, plasma levels of total cholesterol, and leptin. To determine the mechanism, groups of mice were respectively fed a diet containing H. erinaceus powder, a diet containing ethanol extract of H. erinaceus, and a diet containing a residue of the extract. As a result, H. erinaceus powder was found to increase fecal lipid levels in excreted matter. Further in vitro investigation showed that ethanol extract inhibited the activity of lipase, and four lipase-inhibitory compounds were isolated from the extract: hericenone C, hericenone D, hericenone F, and hericenone G. In short, we suggest that H. erinaceus has an anti-obesity effect during menopause because it decreases the ability to absorb lipids. |
| Starting Page | 482 |
| Ending Page | 491 |
| Page Count | 10 |
| File Format | |
| ISSN | 13403443 |
| Journal | Journal of Natural Medicines |
| Volume Number | 71 |
| Issue Number | 3 |
| e-ISSN | 18610293 |
| Language | English |
| Publisher | Springer Japan |
| Publisher Date | 2017-02-08 |
| Publisher Place | Tokyo |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Hericium erinaceus Anti-obesity Menopause Pancreatic lipase inhibition Hericenone Pharmacology/Toxicology Plant Sciences Complementary & Alternative Medicine Medicinal Chemistry Pharmacy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Molecular Medicine Complementary and Alternative Medicine Pharmaceutical Science |
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