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5-Hydroxymethyl-2-furfural, a clinical trials agent for sickle cell anemia, and its mono/di-glucosides from classically processed steamed Rehmanniae Radix

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Journal of Natural Medicines : Volume 62, Issue 1, January 2008

Journal of Natural Medicines : Volume 61

Journal of Natural Medicines : Volume 60

5-Hydroxymethyl-2-furfural, a clinical trials agent for sickle cell anemia, and its mono/di-glucosides from classically processed steamed Rehmanniae Radix

Content Provider	Springer Nature Link
Author	Lin, An Shen Qian, Keduo Usami, Yoshihide Lin, Li Itokawa, Hideji Hsu, Charleson Morris Natschke, Susan L. Lee, Kuo Hsiung
Copyright Year	2007
Abstract	Rehmanniae Radix (Di Huang) is one of the most important traditional Chinese medicines (TCM), and is used for multiple therapeutic purposes. In our investigation of the chemical constituents of Rehmanniae Radix, steamed roots were prepared by the classical processing method. Reversed-phase HPLC of the 50% MeOH extract of steamed Rehmanniae Radix yielded three 5-hydroxymethylfurfural derivatives. The new furfural disaccharide 5-(α-d-glucopyranosyl-(1→6)-α-d-glucopyranosyloxymethyl)-2-furancarboxaldehyde (1) was isolated and characterized, together with its known aglycone 5-hydroxymethyl-2-furfural (3), which is currently in sickle cell anemia Phase I clinical trials, and its corresponding monosaccharide 5-(α-d-glucopyranosyloxymethyl)-2-furancarboxaldehyde (2), which was isolated as a natural product for the first time. The presence of these three compounds, particularly 3, which were not found in the unprocessed extract of Rehmanniae Radix, could substantiate the traditional medicinal use of steamed Rehmanniae Radix.
Starting Page	164
Ending Page	167
Page Count	4
File Format	PDF
ISSN	13403443
Journal	Journal of Natural Medicines
Volume Number	62
Issue Number	2
e-ISSN	18610293
Language	English
Publisher	Springer Japan
Publisher Date	2007-11-01
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Rehmanniae Radix Traditional Chinese medicine (TCM) 5-Hydroxymethylfurfural (5-HMF) Reversed-phase HPLC Pharmacy Medicinal Chemistry Complementary & Alternative Medicine Plant Sciences Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Molecular Medicine Complementary and Alternative Medicine Pharmaceutical Science

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5-Hydroxymethyl-2-furfural, a clinical trials agent for sickle cell anemia, and its mono/di-glucosides from classically processed steamed Rehmanniae Radix

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5-Hydroxymethyl-2-furfural, a clinical trials agent for sickle cell anemia, and its mono/di-glucosides from classically processed steamed Rehmanniae Radix