NDLI: Human hepatocytes express absent in melanoma 2 and respond to hepatitis B virus with interleukin-18 expression

Content Provider	Springer Nature Link
Author	Pan, Xingfei Xu, Haixia Zheng, Changlong Li, Mei Zou, Xiaofang Cao, Hong Xu, Qihuan
Copyright Year	2016
Abstract	Absent in melanoma 2 (AIM2) is a recently recognized cytoplasmic receptor which could sense cytoplasmic double-stranded DNA (dsDNA). After AIM2 detects the presence of parasitic nucleic acids (dsDNA) derived from invasive bacteria or viral genomes (for example, vaccinia virus and cytomegalovirus) within infected cells, AIM2 inflammasome could be formed. The formed AIM2 inflammasome could induce innate immune response and increase expressions of IL-1β and IL-18. Hepatitis B virus (HBV) is a hepatotropic, non-cytopathic double-stranded DNA virus. The immune response to viral antigens or virus is thought to be responsible for both liver damage and viral clearance in patients with HBV infection. However, there are no reports about whether AIM2 inflammasome exists in hepatocytes. In the present study, we investigated the presence and activity of AIM2 inflammasome in human hepatocytes. We found that AIM2 was expressed in cytoplasm of hepatocytes, and IL-18 expression was increased after AIM2 sensed HBV in hepatocytes in vitro. These results showed that AIM2 inflammasome was active in hepatocytes. We also found that hepatic AIM2 expression of chronic hepatitis B (CHB) patients was higher than that of controls. Hepatic AIM2 expression levels were positively correlated to the severity of liver inflammation. IL-18 is already considered to be associated with hepatic injury during HBV infection. In conclusion, we, therefore, believe that AIM2 inflammasome in hepatocytes might play an important role in the development and maintenance of HBV-related hepatitis.
Starting Page	445
Ending Page	452
Page Count	8
File Format	PDF
ISSN	09208569
Journal	Virus Genes
Volume Number	52
Issue Number	4
e-ISSN	1572994X
Language	English
Publisher	Springer US
Publisher Date	2016-04-19
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	AIM2 Hepatocyte HBV Inflammasome Medical Microbiology Virology Plant Sciences
Content Type	Text
Resource Type	Article
Subject	Virology Genetics Medicine Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Complete genomic sequence and phylogenetic relatedness of hepatitis B virus isolates in Cambodia

Novel quasi-subgenotype D2 of hepatitis B virus identified in Taiwanese aborigines

Complete genome sequence and phylogenetic analysis of hepatitis B virus (HBV) isolated from Mongolian patients with chronic HBV infection

Current knowledge on Hepatitis Delta Virus replication

Inflammasome and Autophagy Regulation: A Two-way Street

Comparative analysis of absent in melanoma 2-inflammasome activation in Francisella tularensis and Francisella novicida

The role of microRNAs in hepatocyte metabolism and hepatitis B virus replication

Characterization of Intracellular Precore-Derived Proteins and Their Functions in Hepatitis B Virus-Infected Human Hepatocytes.

Expression of AIM2 is high and correlated with inflammation in hepatitis B virus associated glomerulonephritis

Human hepatocytes express absent in melanoma 2 and respond to hepatitis B virus with interleukin-18 expression

Similar Documents

Complete genomic sequence and phylogenetic relatedness of hepatitis B virus isolates in Cambodia

Novel quasi-subgenotype D2 of hepatitis B virus identified in Taiwanese aborigines

Complete genome sequence and phylogenetic analysis of hepatitis B virus (HBV) isolated from Mongolian patients with chronic HBV infection

Current knowledge on Hepatitis Delta Virus replication

Inflammasome and Autophagy Regulation: A Two-way Street

Comparative analysis of absent in melanoma 2-inflammasome activation in Francisella tularensis and Francisella novicida

The role of microRNAs in hepatocyte metabolism and hepatitis B virus replication

Characterization of Intracellular Precore-Derived Proteins and Their Functions in Hepatitis B Virus-Infected Human Hepatocytes.

Expression of AIM2 is high and correlated with inflammation in hepatitis B virus associated glomerulonephritis

Human hepatocytes express absent in melanoma 2 and respond to hepatitis B virus with interleukin-18 expression