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| Content Provider | Springer Nature Link |
|---|---|
| Author | Li, Shun Edlinger, Marlene Saalfrank, Anja Flisikowski, Krzysztof Tschukes, Alexander Kurome, Mayuko Zakhartchenko, Valeri Kessler, Barbara Saur, Dieter Kind, Alexander Wolf, Eckhard Schnieke, Angelika Flisikowska, Tatiana |
| Copyright Year | 2015 |
| Abstract | Oncogenic mutations of KRAS play a major role in human carcinogenesis. Here we describe viable gene-targeted pigs carrying a latent KRAS $^{ G12D }$ mutant allele that can be activated by Cre recombination. These have been produced as part of a program to model human cancers in pigs by replicating genetic lesions known to initiate and drive human disease. Cre-activated KRAS $^{ G12D }$ animals add to a growing set of gene-targeted pigs that includes a Cre-activated oncogenic mutant TP53, a Cre-responsive dual fluorescent reporter and two truncating mutations of APC (adenomatous polyposis coli). These alleles can be combined and activated in various tissues to produce new models for cancer research. |
| Starting Page | 509 |
| Ending Page | 517 |
| Page Count | 9 |
| File Format | |
| ISSN | 09628819 |
| Journal | Transgenic Research |
| Volume Number | 24 |
| Issue Number | 3 |
| e-ISSN | 15739368 |
| Language | English |
| Publisher | Springer International Publishing |
| Publisher Date | 2015-02-26 |
| Publisher Place | Cham |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cre recombination Disease model Cancer Swine Conditional gene activation KRAS Molecular Medicine Plant Genetics & Genomics Animal Genetics and Genomics Plant Sciences Transgenics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Animal Science and Zoology Biotechnology Agronomy and Crop Science |
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