NDLI: Prospects of a Computational Origin of Life Endeavor

Content Provider	Springer Nature Link
Author	Shenhav, Barak Lancet, Doron
Copyright Year	2004
Abstract	While the last century brought an exquisite understanding of the molecular basis of life, very little is known about the detailed chemical mechanisms that afforded the emergence of life on early earth. There is a broad agreement that the problem lies in the realm of chemistry, and likely resides in the formation and mutual interactions of carbon-based molecules in aqueous medium. Yet, present-day experimental approaches can only capture the synthesis and behavior of a few molecule types at a time. On the other hand, experimental simulations of prebiotic syntheses, as well as chemical analyses of carbonaceous meteorites, suggest that the early prebiotic hydrosphere contained many thousands of different compounds. The present paper explores the idea that given the limitations of test-tube approaches with regards to such a `random chemistry' scenario, an alternative mode of analysis should be pursued. It is argued that as computational tools for the reconstruction of molecular interactions improve rapidly, it may soon become possible to perform adequate computer-based simulations of prebiotic evolution. We thus propose to launch a computational origin of life endeavor (http://ool.weizmann.ac.il/CORE), involving computer simulations of realistic complex prebiotic chemical networks. In the present paper we provide specific examples, based on a novel algorithmic approach, which constitutes a hybrid of molecular dynamics and stochastic chemistry. As one potential solution for the immense hardware requirements dictated by this approach, we have begun to implement an idle CPU harvesting scheme, under the title ool@home.
Starting Page	181
Ending Page	194
Page Count	14
File Format	PDF
ISSN	01696149
Journal	Origins of Life and Evolution of Biospheres
Volume Number	34
Issue Number	1-2
e-ISSN	15730875
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2004-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Organic Chemistry Geochemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Ecology, Evolution, Behavior and Systematics Space and Planetary Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A Fission-Fusion Origin for Life

Photosynthesis and the Origin of Life

Carbonaceous Micrometeorites and the Origin of Life

Montmorillonite, Oligonucleotides, RNA and Origin of Life

Organic Aerosols and the Origin of Life: An Hypothesis

Cyril Ponnamperuma and the Origin of Life: A Bibliography

Origin of Sex Revisited

Asymmetric Spatiotemporal Evolution of Prebiotic Homochirality

The Origin of Life – How Long did it Take?

Prospects of a Computational Origin of Life Endeavor

Similar Documents

A Fission-Fusion Origin for Life

Photosynthesis and the Origin of Life

Carbonaceous Micrometeorites and the Origin of Life

Montmorillonite, Oligonucleotides, RNA and Origin of Life

Organic Aerosols and the Origin of Life: An Hypothesis

Cyril Ponnamperuma and the Origin of Life: A Bibliography

Origin of Sex Revisited

Asymmetric Spatiotemporal Evolution of Prebiotic Homochirality

The Origin of Life – How Long did it Take?

Prospects of a Computational Origin of Life Endeavor