NDLI: Chiral Amplification of Oligopeptides via Polymerization in Two-dimensional Crystallites on Water

Content Provider	Springer Nature Link
Author	Weissbuch, Isabelle Bolbach, Gerard Leiserowitz, Leslie Lahav, Meir
Copyright Year	2004
Abstract	A possible role that might have been played by ordered clusters at the air/water interface for the generation of homochiral oligopeptides under prebiotic conditions has been probed by a catalyzed polymerization of amphiphilic activated α-amino acids that assembled as two-dimensional (2-D) crystallites at this interface. Three type of processes are described: (i) polymerization of racemates of activated α-amino acids that undergo spontaneous resolution into enantiomorphous 2-D crystallites to yield racemic mixtures of oligopeptides enriched with the oligomers of homochiral sequence, (ii) enhanced formation of racemic mixtures of homochiral oligopeptides via lattice-controlled polymerization within 2-D racemic compounds and (iii) generation of homochiral oligopeptides of a single handedness from chiral non-racemic mixtures of monomers that self-assemble into two different phases, racemic crystallites composed from both enantiomers and enantiomorphous crystallites of the enantiomer in excess. The structures of the 2-D crystallites have been determined by grazing incidence X-ray diffraction and the diastereoisomeric composition of the oligopeptides by matrix-assisted laser-desorption time-of-flight mass spectrometry with enantio-labeling.
Starting Page	79
Ending Page	92
Page Count	14
File Format	PDF
ISSN	01696149
Journal	Origins of Life and Evolution of Biospheres
Volume Number	34
Issue Number	1-2
e-ISSN	15730875
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2004-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Organic Chemistry Geochemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Ecology, Evolution, Behavior and Systematics Space and Planetary Science

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