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Plasma Concentrations of Brain-derived Neurotrophic Factor in Patients Undergoing Minor Surgery: A Randomized Controlled Trial

Content Provider	Springer Nature Link
Author	Vutskits, Laszlo Lysakowski, Christopher Czarnetzki, Christoph Jenny, Beit Copin, Jean Christophe Tramèr, Martin R.
Copyright Year	2008
Abstract	We measured perioperative plasma concentrations of brain-derived neurotrophic factor (BDNF), a major mediator of synaptic plasticity in the central nervous system, in males, 30–65 years old, undergoing lumbar or cervical discotomy. Patients were randomly allocated to a general anesthetic with propofol induction and maintenance or with thiopental induction and isoflurane maintenance. BDNF plasma concentrations were measured before induction (baseline), 15 min after induction but before start of surgery, at skin closure, in the post-anesthetic care unit, and 24 h postoperatively. Data from 26 patients (13 in each group) were analyzed. At each time point, BDNF plasma concentrations showed large variability. At baseline, concentrations were 631 ± 337 (mean ± SD) pg ml$^{−1}$ in the propofol group and were 549 ± 512 pg ml$^{−1}$ in the thiopental–isoflurane group (P = 0.31). At 15 min, concentrations significantly decreased in the propofol group (247 ± 219 pg ml$^{−1}$, P = 0.0012 compared with baseline) but remained unchanged in the thiopental–isoflurane group (597 ± 471 pg ml$^{−1}$, P = 0.798 compared with baseline). At skin closure and in the post-anesthetic care unit, concentrations were not different from baseline in both groups. At 24 h, concentrations significantly decreased below baseline in both groups (propofol: 232 ± 129 pg ml$^{−1}$, P = 0.0015; thiopental–isoflurane: 253 ± 250 pg ml$^{−1}$, P = 0.016). In the propofol group, there was a weak but statistically significant positive correlation (R $^{2}$ = 0.38, P = 0.026) between the duration of surgery and BDNF plasma concentrations at skin closure. These data suggest that in males undergoing elective minor surgery, BDNF plasma concentrations show a specific pattern that is influenced by the anesthetic technique and, possibly, by the duration of surgery.
Starting Page	1325
Ending Page	1331
Page Count	7
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	33
Issue Number	7
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2008-02-13
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Anesthesia BDNF Isoflurane Plasma Propofol Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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