NDLI: Reduced Palmitate Turnover in Brain Phospholipids of Pentobarbital-Anesthetized Rats

Content Provider	Springer Nature Link
Author	Contreras, M. A. Chang, M. C. J. Kirkby, D. Bell, J. M. Rapoport, S. I.
Copyright Year	1999
Abstract	Our laboratory has reported that pentobarbital-induced anesthesia reduced the incorporation of intravenously injected radiolabeled palmitic acid into brain phospholipids. To determine if this decrease reflected a pentobarbital-induced decrease in palmitate turnover in phospholipids, we applied our method and model to study net flux and turnover of palmitate in brain phospholipids (1). Awake, light and deep pentobarbital (25–70 mg/kg, iv) anesthetized rats were infused with [9,10-$^{3}$H]palmitate over a 5 min period. Brain electrical activity was monitored by electroencephalography. An isoelectric electroencephalogram characterized deep pentobarbital anesthesia. Net incorporation rates (J $_{FA,i }$) and turnover rates (F $_{i}$) of palmitate were calculated. J $_{FA,i }$ for palmitate incorporated into phospholipids was dramatically reduced by pentobarbital treatment in a dose-dependent manner, by 70% and 90% respectively for lightly and deeply anesthetized animals, compared with awake controls. Turnover rates for palmitate in total phospholipid and individual phospholipid classes were decreased by nearly 70% and 90% for lightly and deeply anesthetized animals, respectively. Thus, pentobarbital decreases, in a dose-dependent manner, the turnover of palmitate in brain phospholipids. This suggests that palmitate turnover is closely coupled to brain functional activity.
Starting Page	833
Ending Page	841
Page Count	9
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	24
Issue Number	7
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	1999-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Turnover of Myelin Lipids in Aging Brain

Manoalide, a Phospholipase A$_{2}$ Inhibitor, Inhibits Arachidonate Incorporation and Turnover in Brain Phospholipids of the Awake Rat

Role of NMDA Receptors in Pentobarbital Tolerance/Dependence

Comparison of Glutamate Turnover in Nerve Terminals and Brain Tissue During [1,6-$^{13}$C$_{2}$]Glucose Metabolism in Anesthetized Rats

Epilepsy, Neurodegeneration, and Extracellular Glutamate in the Hippocampus of Awake and Anesthetized Rats Treated with Okadaic Acid

Changes of the Level of G Protein α-Subunit mRNA by Tolerance to and Withdrawal from Pentobarbital in Rats

Proline Reduces Creatine Kinase Activity in the Brain Cortex of Rats

Brain Monoamine Changes in Rats After Short Periods of Ozone Exposure

In Vivo Fatty Acid Incorporation into Brain Phospholipids in Relation to Signal Transduction and Membrane Remodeling

Reduced Palmitate Turnover in Brain Phospholipids of Pentobarbital-Anesthetized Rats

Similar Documents

Turnover of Myelin Lipids in Aging Brain

Manoalide, a Phospholipase A$_{2}$ Inhibitor, Inhibits Arachidonate Incorporation and Turnover in Brain Phospholipids of the Awake Rat

Role of NMDA Receptors in Pentobarbital Tolerance/Dependence

Comparison of Glutamate Turnover in Nerve Terminals and Brain Tissue During [1,6-$^{13}$C$_{2}$]Glucose Metabolism in Anesthetized Rats

Epilepsy, Neurodegeneration, and Extracellular Glutamate in the Hippocampus of Awake and Anesthetized Rats Treated with Okadaic Acid

Changes of the Level of G Protein α-Subunit mRNA by Tolerance to and Withdrawal from Pentobarbital in Rats

Proline Reduces Creatine Kinase Activity in the Brain Cortex of Rats

Brain Monoamine Changes in Rats After Short Periods of Ozone Exposure

In Vivo Fatty Acid Incorporation into Brain Phospholipids in Relation to Signal Transduction and Membrane Remodeling

Reduced Palmitate Turnover in Brain Phospholipids of Pentobarbital-Anesthetized Rats