NDLI: In vitro Antioxidant Activity of Valeriana officinalis Against Different Neurotoxic Agents

Content Provider	Springer Nature Link
Author	Sudati, Jéssie Haigert Fachinetto, Roselei Pereira, Romaiana Picada Boligon, Aline Augusti Athayde, Margareth Linde Soares, Felix Antunes Vargas Barbosa, Nilda Berenice Rocha, João Batista Teixeira
Copyright Year	2009
Abstract	Valeriana officinalis L. (Valerian) is widely used as a traditional medicine to improve the quality of sleep. Although V. officinalis have been well documented as promising pharmacological agent; the exact mechanisms by which this plant act is still unknown. Limited literature data have indicated that V. officinalis extracts can exhibit antioxidant properties against iron in hippocampal neurons in vitro. However, there is no data available about the possible antioxidant effect of V. officinalis against other pro-oxidants in brain. In the present study, the protective effect of V. officinalis on lipid peroxidation (LPO) induced by different pro-oxidant agents with neuropathological importance was examined. Ethanolic extract of valerian (0–60 μg/ml) was tested against quinolinic acid (QA); 3-nitropropionic acid; sodium nitroprusside; iron sulfate (FeSO$_{4}$) and Fe$^{2+}$/EDTA induced LPO in rat brain homogenates. The effect of V. officinalis in deoxyribose degradation and reactive oxygen species (ROS) production was also investigated. In brain homogenates, V. officinalis inhibited thiobarbituric acid reactive substances induced by all pro-oxidants tested in a concentration dependent manner. Similarly, V. officinalis caused a significant decrease on the LPO in cerebral cortex and in deoxyribose degradation. QA-induced ROS production in cortical slices was also significantly reduced by V. officinalis. Our results suggest that V. officinalis extract was effective in modulating LPO induced by different pro-oxidant agents. These data may imply that V. officinalis extract, functioning as antioxidant agent, can be beneficial for reducing insomnia complications linked to oxidative stress.
Starting Page	1372
Ending Page	1379
Page Count	8
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	34
Issue Number	8
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2009-02-04
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Valeriana officinalis Ethanolic extract Pro-oxidant agents TBARS Deoxyribose degradation Oxidative stress Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cytoprotective Effect of Valeriana officinalis Extract on an In Vitro Experimental Model of Parkinson Disease

Pro-oxidant status based alterations in cerebellar antioxidant response to aluminum insult

Antioxidant Effects of Different Extracts from Melissa officinalis, Matricaria recutita and Cymbopogon citratus

N-methyl-D-aspartate Receptors are Involved in the Quinolinic Acid, but not in the Malonate Pro-oxidative Activity in vitro

2-Deoxyribose Deprives Cultured Astrocytes of their Glutathione

Augmentation of Aluminum-Induced Oxidative Stress in Rat Cerebrum by Presence of Pro-oxidant (Graded Doses of Ethanol) Exposure

Ceruloplasmin Protects Against Rotenone-Induced Oxidative Stress and Neurotoxicity

Catuaba (Trichilia catigua) Prevents Against Oxidative Damage Induced by In Vitro Ischemia–Reperfusion in Rat Hippocampal Slices

Neurotoxic Effects of Methamphetamine

In vitro Antioxidant Activity of Valeriana officinalis Against Different Neurotoxic Agents

Similar Documents

Cytoprotective Effect of Valeriana officinalis Extract on an In Vitro Experimental Model of Parkinson Disease

Pro-oxidant status based alterations in cerebellar antioxidant response to aluminum insult

Antioxidant Effects of Different Extracts from Melissa officinalis, Matricaria recutita and Cymbopogon citratus

N-methyl-D-aspartate Receptors are Involved in the Quinolinic Acid, but not in the Malonate Pro-oxidative Activity in vitro

2-Deoxyribose Deprives Cultured Astrocytes of their Glutathione

Augmentation of Aluminum-Induced Oxidative Stress in Rat Cerebrum by Presence of Pro-oxidant (Graded Doses of Ethanol) Exposure

Ceruloplasmin Protects Against Rotenone-Induced Oxidative Stress and Neurotoxicity

Catuaba (Trichilia catigua) Prevents Against Oxidative Damage Induced by In Vitro Ischemia–Reperfusion in Rat Hippocampal Slices

Neurotoxic Effects of Methamphetamine

In vitro Antioxidant Activity of Valeriana officinalis Against Different Neurotoxic Agents