NDLI: Curcumin-Induced DNA Damage and Inhibited DNA Repair Genes Expressions in Mouse

Content Provider	Springer Nature Link
Author	Lu, Hsu Feng Yang, Jai Sing Lai, Kuang Chi Hsu, Shu Chun Hsueh, Shu Ching Chen, Yuan Liang Chiang, Jo Hua Lu, Chi Cheng Lo, Chyi Yang, Mei Due Chung, Jing Gung
Copyright Year	2009
Abstract	Curcumin is reported to be a potent inhibitor of the initiation and promotion of many cancer cells. We investigated to examine whether or not curcumin induce DNA damage in mouse–rat hybrid retina ganglion cell line N18 cells. The Comet assay showed that incubation of N18 cells with 10, 25 and 30 μM of curcumin led to a longer DNA migration smear (Comet tail). The DNA gel electrophoresis showed that 20 μM of curcumin for 24 and 48 h treatment induced DNA damage and fragments in N18 cells. The real time PCR analysis showed that 20 μM of curcumin for 48 h treatment decreased ATM, ATR, BRCA1, 14-3-3σ, DNA-PK and MGMT mRNA, and ATM and MGMT mRNA expression were inhibited in a time-dependent manner. Our results indicate that curcumin caused DNA damage and inhibited DNA repair genes which may be the factors for curcumin-inhibited cell growth.
Starting Page	1491
Ending Page	1497
Page Count	7
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	34
Issue Number	8
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2009-03-05
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Curcumin DNA damage DNA repair N18 mouse–rat hybrid retina ganglion cells Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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