NDLI: Glutamate Receptor Desensitization Block Potentiates the Stimulated GABA Release Through External Ca2+-Independent Mechanisms from Granule Cells of Olfactory Bulb

Content Provider	Springer Nature Link
Author	Jaffe, E. H. Figueroa, L.
Copyright Year	2001
Abstract	Glutamate stimulated release of [$^{3}$H]GABA was studied, during receptor desensitization block and its modulation by voltage gated Ca$^{2+}$ channels, internal Ca$^{2+}$ mobilization and GABA transport inhibitors from olfactory bulb slices. Under control conditions, glutamate and agonists induced release was strongly inhibited by Mg/0 Ca$^{2+}$ Krebs and Cd$^{2+}$ and partially inhibited by Ni$^{2+}$ and nifedipine. Cyclothiazide, which blocks desensitization of glutamate receptors, potentiated glutamate, kainate, AMPA and quisqualate induced release. This effect was less dependent of entry of external Ca$^{2+}$, but was inhibited by trifluoperazine and thapsigargin, inhibitors of Ca$^{2+}$-calmodulin and endoplasmatic Ca$^{2+}$ ATPase respectively. Nipecotic acid and NO-711, inhibitors of the GABA transporter, were also able to reduce cyclothiazide potentiated release induced by the 4 secretagogues. Under control conditions, glutamate stimulates the release of GABA in cooperation with VDCC. However, during receptor desensitization block, glutamate stimulated GABA release is mainly modulated through mechanisms dependent on internal Ca$^{2+}$ mobilization and reversal of the GABA transporter.
Starting Page	1177
Ending Page	1185
Page Count	9
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	26
Issue Number	11
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2001-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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