NDLI: Metabotropic Glutamate Receptors Modulate GABA Release from Mouse Hippocampal Slices

Content Provider	Springer Nature Link
Author	Saransaari, Pirjo Oja, Simo S.
Copyright Year	2001
Abstract	The effects of metabotropic glutamate receptor agonists on the basal and potassium (50 mM K$^{+}$)-stimulated release of [$^{3}$H]GABA from mouse hippocampal slices were investigated using a superfusion system. The group I agonist (1±)-1-aminocyclopentane-trans-1,3-dicarboxylate enhanced the basal GABA release and reduced the K$^{+}$-evoked release by a mechanism antagonized by (RS)-1-aminoindan-1,5-dicarboxylate in both cases. The group II agonist (2S,2′R,3′R)-2-(2′,3′-dicarboxycyclopropyl)glycine failed to have any effect on the basal release, but inhibited the stimulated release. This inhibition was not affected by the antagonist (2S)-2-ethylglutamate. The group III agonists L(+)-amino-4-phosphonobutyrate and O-phospho-L-serine inhibited the basal GABA release, which effects were blocked by the antagonist (RS)-2-cyclopropyl-4-phosphonophenylglycine. Moreover, the suppression of the K$^{+}$-evoked release by L(+)2-amino-4-phosphonobutyrate was apparently receptor-mediated, being blocked by (RS)-2-cyclopropyl-4-phosphonophenylglycine. The results show that activation of metabotropic glutamate receptors of group I is able to potentiate the basal release of GABA, whereas activation of groups I and III receptors reduce K$^{+}$-stimulated release in mouse hippocampal slices.
Starting Page	175
Ending Page	180
Page Count	6
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	26
Issue Number	2
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2001-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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