NDLI: EGb761 Blocks MPP+-Induced Lipid Peroxidation in Mouse Corpus Striatum

Content Provider	Springer Nature Link
Author	Rojas, Patricia Garduño, Belén Rojas, Carolina Vigueras, Rosa María Rojas Castañeda, Julio Ríos, Camilo Serra Garcia, rma
Copyright Year	2001
Abstract	EGb761 has been suggested to be an antioxidant and free radical scavenger. Excess generation of free radicals, leading to lipid peroxidation (LP), has been proposed to play a role in the damage to striatal neurons induced by 1-methyl-4-phenylpyridinium (MPP$^{+}$). We investigated the effects of EGb761 pretreatment on MPP$^{+}$ neurotoxicity. C-57 black mice were pretreated with EGb761 for 17 days at different doses (0.63, 1.25, 2.5, 5 or 10 mg/kg) followed by administration of MPP$^{+}$, (0.18, 0.36 or 0.72 mg/kg). LP was analyzed in corpus striatum at 30 min, 1 h, 2 h and 24 h after MPP$^{+}$ administration. Striatal dopamine content was analyzed by HPLC at the highest EGb761 dose at 2 h and 24 h after MPP$^{+}$ administration. MPP$^{+}$-induced LP was blocked (100%) by EGb761 (10 mg/kg). Pretreatment with EGb761 partially prevented (32%) the dopamine-depleting effect of MPP$^{+}$ at 24 h. These results suggest that supplements of EGb761 may be effective at preventing MPP$^{+}$-induced oxidative stress.
Starting Page	1245
Ending Page	1251
Page Count	7
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	26
Issue Number	11
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2001-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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