NDLI: Elevated Inflammatory Markers in a Group of Amyotrophic Lateral Sclerosis Patients from Northern India

Content Provider	Springer Nature Link
Author	Babu, G. Nagesh Kumar, Alok Chandra, Ramesh Puri, S. K. Kalita, Jayantee Misra, U. K.
Copyright Year	2007
Abstract	The role of cytokines in the pathophysiology of amyotrophic lateral sclerosis (ALS) and its relation to clinical outcome has not been clearly defined. We evaluated tumor necrosis factor-alpha (TNF-α), interferon-γ (IFN-γ) and nitric oxide (NO) levels in the serum of 22 ALS patients and 20 controls. Serum TNF-α levels and IFN-γ levels were significantly (P < 0.001) elevated in ALS patients. We also observed NO levels to be significantly (P < 0.05) increased with respect to normal subjects. We further noticed positive correlation between the duration of ALS and these proinflammatory molecule levels. Exitotoxicity and oxidative stress are known to play a crucial role in the neurodegeneration observed in ALS. Since high levels of TNF-α are known to be cytotoxic, it could be that a complex interplay of these effectors may be one of the factors underlying the progression of ALS. This study confirms the involvement of inflammation in ALS and the need to develop surrogate markers to check the progression of this disease.
Starting Page	1145
Ending Page	1149
Page Count	5
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	33
Issue Number	6
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2008-02-02
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Amyotrophic lateral sclerosis Tumor necrosis factor-α Interferon-γ Nitric oxide Inflammation Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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