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Role of Tuberin in Neuronal Degeneration

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Role of Tuberin in Neuronal Degeneration

Content Provider	Springer Nature Link
Author	Habib, Samy L. Michel, David Masliah, Eliezer Thomas, Bobby Ko, Han Seok Dawson, Ted M. Abboud, Hanna Clark, Robert A. Imam, Syed Z.
Copyright Year	2008
Abstract	One of the tuberous sclerosis complex (TSC) gene products, tuberin is assumed to be the functional component, being involved in a wide variety of cellular processes. Here, we report for the first time that tuberin dysfunction may represent a mechanism for neuronal damage in Alzheimer’s disease (AD), Parkinson’s disease with dementia (PD/DLB), and a mouse model of PD. Tuberin was hyperphosphorylated at Thr1462 in post-mortem frontal cortex tissue of both AD and PD/DLB patients and in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP). Both PTEN and Akt phosphoactivation corresponded to the hyperphosphorylation patterns of tuberin suggesting that the PTEN–Akt pathway might be the mechanism of tuberin phosphorylation. Our data provide new information regarding the possible role of tuberin dysfunction in major neurodegenerative disorders, such as AD and PD, whereby inhibition of tuberin function may trigger an onset of neuronal cell death.
Starting Page	1113
Ending Page	1116
Page Count	4
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	33
Issue Number	6
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2008-03-05
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Tuberous sclerosis complex Parkinson's disease Alzheimer's disease Tuberin Akt Neurodegeneration Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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