NDLI: Transcription Factor GATA-3 Regulates the Transcriptional Activity of Dopamine β-Hydroxylase by Interacting with Sp1 and AP4

Content Provider	Springer Nature Link
Author	Hong, Seok Jong Choi, Hyun Jin Hong, Sunghoi Huh, Youngbuhm Chae, Han Kim, Kwang Soo
Copyright Year	2008
Abstract	GATA-3 is a zinc finger transcription factor that is expressed in T cell lineages as well as in the nervous system during development. In this study, we report that forced expression of GATA-3 resulted in an increased number of dopamine β-hydroxylase (DBH)-expressing neurons in primary neural crest stem cell (NCSC) culture, suggesting that the DBH gene may be a downstream target gene of GATA-3. GATA-3 robustly transactivates the promoter function of the noradrenaline (NA)-synthesizing DBH gene, via two specific upstream promoter domains; one at −62 to −32 bp and the other at −891 to −853 bp. Surprisingly, none of these domains contain GATA-3 binding sites but encompass binding motifs for transcription factors Sp1 and AP4, respectively. Protein–protein interaction analyses both in vitro and in vivo and chromatin immunoprecipitation (ChIP) assays showed that GATA-3 effects its transcriptional regulatory function through physical interactions with these transcription factors.
Starting Page	1821
Ending Page	1831
Page Count	11
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	33
Issue Number	9
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2008-03-13
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	GATA-3 Sp1 AP4 siRNA ChIP assay Dopamine β-hydroxylase Protein–protein interaction Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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