NDLI: Mitochondria are More Resistant to Hypoxic Depolarization in the Newborn than in the Adult Brain

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Mitochondria are More Resistant to Hypoxic Depolarization in the Newborn than in the Adult Brain

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Mitochondria are More Resistant to Hypoxic Depolarization in the Newborn than in the Adult Brain

Content Provider	Springer Nature Link
Author	Larsen, Geir Arne Skjellegrind, Håvard K. Vinje, Morten Larsen Berg Johnsen, Jon
Copyright Year	2008
Abstract	Hypoxic–ischemic brain injury subsequent to asphyxia represents a major cause of morbidity and death in the newborn. The newborn brain has been considered more resistant to hypoxia than the adult brain because of lower energy demand. The mechanisms underlying hypoxic brain injury, in particular the age-related vulnerability, are still only partially understood. The mitochondrial function is pivotal for the function and survival of neurons. Acutely isolated CA1 neurons from neonatal (3–6 days) and adult rats (5–6 weeks) were loaded with Rh 123, and the effect of hypoxia on the inner mitochondrial membrane potential (Δψ$_{m}$) was compared. During prolonged hypoxia (15 min), Δψ$_{m}$ was lost in a majority of the neonatal neurons (83%) and in all the adult neurons. During hypoxia (5 min) followed by reoxygenation the mitochondria in 23% of the neonatal neurons were completely depolarized, whereas 85% of the adult neurons demonstrated a complete loss of Δψ$_{m}$. In conclusion hippocampal CA1 mitochondria in the newborn rat are more resistant to hypoxic depolarization than in the adult rat.
Starting Page	1894
Ending Page	1900
Page Count	7
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	33
Issue Number	9
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2008-03-25
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mitochondrial membrane potential Hippocampus CA1 neurons Hypoxia Rhodamine 123 Neonatal brain Age Hypoxic tolerance Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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