NDLI: The biological properties of the silver- and copper-doped ceramic biomaterial

Content Provider	Springer Nature Link
Author	Lysenko, Oleksandr Dubok, Oleksii Borysenko, Anatolii Shinkaruk, Oleksandr
Copyright Year	2015
Abstract	The biological properties of nanostructured bioactive ceramic composite (BCC) granules doped with 0.1–10 at.% silver and 0.05–5 at.% copper have been investigated both in vitro and in vivo to develop effective alloplastic material for infected bone defect substitute. It is assumed that the granules consisting of biphasic calcium phosphate and bioactive glass ceramics due to their nanoscale (15–40 nm) and multiphase structure, bioelement placement in different ceramic phases as well as antimicrobial effect should improve osteogenic properties and biocompatibility. Tests in vitro have been conducted with multipotent mesenchymal stromal cells (MSCs) and test strains of microorganisms. The same biocomposite has been used in vivo to study the repair of bone defects in animal model. The findings indicate that doped BCC leads to antimicrobial activity. Inhibition of MSCs growth has been observed for granules doped with ions of more than 1 at.% silver and 0.5 at.% copper. The results of the in vivo study reveal that BCC implantation significantly improves bone reparation. Differences between bone repair with undoped and doped, with 1 at.% silver and 0.5 at.% copper, ceramic samples were not observed. The BCC doped within 0.5–1 at.% silver and 0.25–0.5 at.% copper stimulates bone tissue repair and has satisfactory biocompatibility and antimicrobial properties.
Starting Page	1
Ending Page	15
Page Count	15
File Format	PDF
ISSN	13880764
Journal	Journal of Nanoparticle Research
Volume Number	17
Issue Number	4
e-ISSN	1572896X
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-04-10
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Bioactive ceramics Nanocrystallinity Silver and copper Antimicrobial Cytotoxicity Osteogenesis Bioinspired nanomaterials Nanotechnology Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Optoelectronics, Plasmonics and Optical Devices
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation

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