NDLI: Utilizing inverse micelles to synthesize calcium phosphate nanoparticles as nano-carriers

Content Provider	Springer Nature Link
Author	Han, Jamie YuLing Tan, Timothy Thatt Yang Loo, Joachim Say Chye
Copyright Year	2011
Abstract	The aim of this study was to investigate the feasibility of the inverse micelles (IM) technique in producing protein-loaded calcium phosphate nanoparticles (CaP NPs), and to compare this technique with the conventional co-precipitation (co-ppt) technique. In this study, bovine serum albumin and lysozyme were used as model proteins. The results show that CaP NPs produced by IM were shown to be spherical and homogenous in size of ~50 nm. Protein loading efficiency of the IM technique was shown to be much higher than CaP NPs synthesized through co-ppt technique. X-ray photoelectron spectroscopy shows that proteins were not adsorbed onto the surface of IM-synthesized CaP NPs, which suggested that the proteins were entrapped within the particle matrix. Release studies show that protein release was more rapid at lower pH conditions (pH 5 and 6) than at physiological pH of 7.4. A burst release was observed for co-ppt CaP NPs, while a continuous release of protein was observed for IM-produced CaP NPs. This study shows the superiority of the IM technique in preparing pH responsive CaP NPs as nano-carriers.
Starting Page	3441
Ending Page	3454
Page Count	14
File Format	PDF
ISSN	13880764
Journal	Journal of Nanoparticle Research
Volume Number	13
Issue Number	8
e-ISSN	1572896X
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-02-12
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Calcium phosphate Nanoparticles Protein release Protein carriers Bovine serum ablumin carriers Lysozyme carriers Inverse micelles synthesis Protein delivery Reverse emulsion synthesis Rhodamine 6G Colloids Inorganic Chemistry Optics, Optoelectronics, Plasmonics and Optical Devices Physical Chemistry Characterization and Evaluation of Materials Nanotechnology
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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