NDLI: Biodistribution of rhodamine B fluorescence-labeled cationic nanoparticles in rats

Content Provider	Springer Nature Link
Author	Knudsen, Kristina Bram rtheved, Helle Gjetting, Torben Permin, Anders Andresen, Thomas L. Wegener, Karen Malene Lam, Henrik Rye Lykkesfeldt, Jens
Copyright Year	2014
Abstract	We investigated the biodistribution following the administration of nanosized (about 50 and 90 nm) cationic (ζ: +30 and +50 mV) micelles and liposomes intended for drug delivery. The particles were stable and well characterized with respect to size and ζ potential. Ten 5- to 6-week-old male rats were used. The animals were randomly allocated to five groups receiving either cationic micelles or cationic liposomes by single intravenous (IV) administration at a dose of 100 mg/kg bodyweight by single intracerebroventricular (ICV) injection at a dose of 50 μg or no treatment. ICV administration was used to study local distribution in the brain and IV administration to study the systemic distribution of the particles. For both types of particles, ICV administration showed distribution in all ventricles in the brain while IV delivery displayed distribution to the major organs liver, spleen, kidney and lung, but not to the brain. Our data suggest that cationic micelles and liposomes are widely distributed in the body, indicating that these could potentially be used as drug delivery carriers to the major organs, but they do not cross the blood–brain barrier to a significant extent, without a targeting ligand attached. However, they are able to persist in the ventricles of the brain up to 24 h after ICV administration, demonstrating a new ability.
Starting Page	1
Ending Page	11
Page Count	11
File Format	PDF
ISSN	13880764
Journal	Journal of Nanoparticle Research
Volume Number	16
Issue Number	2
e-ISSN	1572896X
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-01-04
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Micelles Liposomes Distribution Nanotechnology Rhodamine B Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Optoelectronics, Plasmonics and Optical Devices
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation

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