NDLI: Role of tissue plasminogen activator and plasminogen activator inhibitor polymorphism in myocardial infarction

Content Provider	Springer Nature Link
Author	Ahmed, Waqas Malik, Meera Saeed, Imran Khan, Amina Ali Sadeque, Ahmed Kaleem, Umar Ahmed, Nuzhat Ajmal, Muhammad Azam, Maleeha Qamar, Raheel
Copyright Year	2010
Abstract	A case–control association study on 229 Myocardial Infarction (MI) patients and 217 healthy controls was carried out to determine the role of tissue-plasminogen activator (t-PA) (Alu-repeat insertion (I)/deletion (D)) and plasminogen activator inhibitor (PAI-1) (4G/5G insertion/deletion) polymorphisms with MI in the Pakistani population. In MI patients the genotype distribution of the PAI-1 gene was not found to be different when compared with the unaffected controls (P > 0.05, χ$^{2}$ = 1.03). The risk allele 4G was also not associated with MI (P > 0.05, χ$^{2}$ = 0.46, odds ratio (OR) = 1.1 (95% confidence interval (CI) = 0.84–1.43), P > 0.05). Similarly, the genotype frequencies of t-PA I/I, I/D and D/D were not different from the unaffected controls (P > 0.05, χ$^{2}$ = 1.60), and the risk allele “I” was not found to be associated with MI (P > 0.05, χ$^{2}$ = 1.35, OR = 0.86 (95% CI = 0.66–1.11), P > 0.05). However, when the data were distributed along the lines of gender a significant association of the 4G/4G PAI-1 genotype was observed with only the female MI patients (P < 0.05, z-test = 2.21). When the combined genotypes of both the polymorphisms were analyzed, a significant association of MI was observed with the homozygous DD/4G4G genotype (P < 0.01, z-test = 2.61), which was specifically because of the female samples (P = 0.01, z-test = 2.53). In addition smoking (P < 0.001, χ$^{2}$ = 13.52, OR = 3.45 (95% CI = 1.77–6.94)), diabetes (P < 0.001, χ$^{2}$ = 22.45, OR = 8.89 (95% CI = 2.96–29.95)), hypertension (OR = 7.76 (95% CI = 2.88–22.68), P < 0.001) family history (P < 0.001, χ$^{2}$ = 13.72, OR = 3.7 (95% CI = 1.71–8.18)) and lower HDL levels (P < 0.05) were found to be significantly associated with the disease. In conclusion the PAI-1 gene polymorphism was found to have a gender specific role in the female MI patients.
Starting Page	2541
Ending Page	2548
Page Count	8
File Format	PDF
ISSN	03014851
Journal	Molecular Biology Reports
Volume Number	38
Issue Number	4
e-ISSN	15734978
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-11-17
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Myocardial infarction Tissue-plasminogen activator Plasminogen activator inhibitor Coronary artery disease Animal Biochemistry Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Molecular Biology

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